{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:31:44Z","timestamp":1777458704991,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sleep\u2010disordered breathing (SDB) and Cheyne\u2010Stokes respiration (CSR) are associated with shorter survival in patients with heart failure. A novel treatment method for this patient group is unilateral phrenic nerve stimulation by the remed\u0113\u00ae system (Respicardia Inc., Minnetonka, MN, USA), a transvenously implantable neurostimulation device, which has recently been studied in a large randomized, controlled trial. Previous literature has shown efficacy and safety of the treatment with this first\u2010generation device, but hardly any data are available on long\u2010term clinical parameters, the remed\u0113\u00ae device's battery lifetime, device exchangeability, lead position stability, surgical accessibility, and manageability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed remed\u0113\u00ae device replacements in consecutive patients for battery depletion, and documented clinical parameters, longevity, operation procedure, complications, and difficulties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were on neurostimulation treatment by phrenic nerve neurostimulation when device replacement became necessary. Apnea\u2010hypopnea index (from 45 \u00b1 4\/h to 9 \u00b1 4\/h), oxygen\u2010desaturation index (from 35 \u00b1 7\/h to 7 \u00b1 6\/h), and time spent with oxygen saturation of &lt;90% (T &lt; 90% from 5 \u00b1 7% to 0 \u00b1 0%) were improved and improvements remained constant throughout the 4\u2010year follow\u2010up. Mean battery life was 4.2 \u00b1 0.2 years and mean replacement procedure time was 25 \u00b1 5.1 minutes. Apart from conventional X\u2010ray documentation of stable lead positions in a long\u2010term setting, no radiation or contrast dye usage was needed and no major complications occurred. In addition, clinical exercise capacity and sleepiness symptoms improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Novel remed\u0113\u00ae device shows sustained therapy efficacy and safety in terms of stable lead positions over 4 years. Long\u2010term phrenic nerve neurostimulation therapy for central SDB\/CSR appears feasible in a clinical routine setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13049","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T14:27:48Z","timestamp":1487341668000},"page":"498-503","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010Term Experience with First\u2010Generation Implantable Neurostimulation Device in Central Sleep Apnea Treatment"],"prefix":"10.1111","volume":"40","author":[{"given":"HENRIK","family":"FOX","sequence":"first","affiliation":[{"name":"Clinic for Cardiology Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"BITTER","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen 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