{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:42Z","timestamp":1787015862501,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal cord stimulation (SCS) reduces sympathetic activity in animal models of heart failure with reduced ejection fraction (HF) but limited data exist of SCS in patients with HF. The aim of the present study was to test the primary hypothesis that SCS reduces cardiac sympathetic nerve activity in HF patients. Secondary hypotheses were that SCS improves left ventricular function and dimension, exercise capacity, and clinical variables relevant to HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      HF patients with a SCS device previously participating in the DEFEAT\u2010HF trial were included in this crossover study with 6\u2010week intervention periods (SCS\u2010ON and SCS\u2010OFF). SCS (50 Hz, 210\u2010\u03bcs pulse duration, aiming at T2\u2013T4 segments) was delivered for 12 hours daily. Indices of myocardial sympathetic neuronal function (heart\u2010to\u2010mediastinum ratio, HMR) and activity (washout rate, WR) were assessed using\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010metaiodobenzylguanidine (MIBG) scintigraphy. Echocardiography, exercise testing, and clinical data collection were also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 13 patients (65.3 \u00b1 8.0 years, nine males) and MIBG scintigraphy data were available in 10. HMR was not different comparing SCS\u2010ON (1.37 \u00b1 0.16) and SCS\u2010OFF (1.41 \u00b1 0.21, P = 0.46). WR was also unchanged comparing SCS\u2010ON (41.5 \u00b1 5.3) and SCS\u2010OFF (39.1 \u00b1 5.8, P = 0.30). Similarly, average New York Heart Association class (2.4 \u00b1 0.5 vs 2.3 \u00b1 0.6, P = 0.34), quality of life score (24 \u00b1 16 vs 24 \u00b1 16, P = 0.94), and left ventricular dimension and function as well as exercise capacity were all unchanged comparing SCS\u2010ON and SCS\u2010OFF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with HF, SCS (12 hours daily, targeting the T2\u2013T4 segments of the spinal cord) does not appear to influence cardiac sympathetic neuronal activity or function as assessed by MIBG scintigraphy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.13050","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T06:52:40Z","timestamp":1487227960000},"page":"504-513","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Spinal Cord Stimulation on Cardiac Sympathetic Nerve Activity in Patients with Heart Failure"],"prefix":"10.1111","volume":"40","author":[{"given":"JAN","family":"NAAR","sequence":"first","affiliation":[{"name":"Department of Cardiology Na Homolce Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEBORAH","family":"JAYE","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm and Heart Failure Medtronic Plc  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CECILIA","family":"LINDE","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, and Department of Cardiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETR","family":"NEU\u017dIL","sequence":"additional","affiliation":[{"name":"Department of Cardiology Na Homolce Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETR","family":"DO\u0160K\u00c1\u0158","sequence":"additional","affiliation":[{"name":"Department of Cardiology Na Homolce Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FILIP","family":"M\u00c1LEK","sequence":"additional","affiliation":[{"name":"Department of Cardiology Na Homolce Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRIEDER","family":"BRAUNSCHWEIG","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, and Department of Cardiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LARS H.","family":"LUND","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, and Department of Cardiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LARS","family":"MORTENSEN","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, and Department of Cardiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BENGT","family":"LINDEROTH","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet and Department of Neurosurgery Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00d6RAN","family":"LIND","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet and Department of Neurosurgery Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIANNA","family":"BONE","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, and Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARTHUR J.","family":"SCHOLTE","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRED","family":"KUEFFER","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm and Heart Failure Medtronic Plc  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JODI","family":"KOEHLER","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm and Heart Failure Medtronic Plc  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAMBIZ","family":"SHAHGALDI","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Sunderby Hospital  Lule\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OTTO","family":"LANG","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Kr\u00e1lovsk\u00e9 Vinohrady  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCUS","family":"ST\u00c5HLBERG","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Karolinska Institutet, and Department of Cardiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90167-L"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00095-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.812412"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1491-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.014"},{"key":"e_1_2_8_7_1","first-page":"845","article-title":"Improvement of cardiac neuronal function after carvedilol treatment in dilated cardiomyopathy: A 123I\u2010MIBG scintigraphic study","volume":"41","author":"Agostini D","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.10.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2002.002998"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02174.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015197"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03007362"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00377-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu409"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-014-9547-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02230.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.07.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.12.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.107"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum081"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.04.025"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:19:06Z","timestamp":1696497546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/pace.13050"],"URL":"https:\/\/doi.org\/10.1111\/pace.13050","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}