{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:50Z","timestamp":1791231290357,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) has proved to be effective in patients with heart failure and left bundle branch block (LBBB). Recently, new electrocardiography criteria have been proposed for the diagnosis of LBBB. These criteria are stricter than the current American Heart Association (AHA) criteria. We assessed the rate of echocardiographic response to CRT in patients with traditional LBBB versus patients who met the new criteria (strict LBBB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing CRT were enrolled in the CRT MORE registry. Patients with no\u2010LBBB QRS morphology according to AHA criteria, atrial fibrillation, right bundle branch block, and right ventricular pacing were excluded. Strict LBBB was defined as: QRS \u2265 140\u00a0ms for men and \u2265130 ms for women, QS or rS in V1\u2013V2, mid\u2010QRS notching or slurring in \u22652 contiguous leads. Patients showing a relative decrease of \u226515% in left ventricular end\u2010systolic volume (LVESV) at 12 months were defined as responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 335 patients with LBBB, 131 (39%) had strict LBBB. Patients with and without strict LBBB showed comparable baseline characteristics, except for QRS duration (166 \u00b1 20 ms vs 152 \u00b1 25 ms, P &lt; 0.001). On 12\u2010month evaluation, 205 patients (61%) were responders; 85 of 131 (65%) had strict LBBB and 120 of 204 (59%) had traditional LBBB (P = 0.267). On multivariate analysis, a history of atrial fibrillation, larger LVESV, and the presence of mid\u2010QRS notching in \u22651 lead (odds ratio 2.099; 95% confidence interval 1.061\u20134.152, P = 0.033) were independently associated with echocardiographic response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stricter definition of LBBB did not improve response to CRT in comparison to the current AHA definition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13104","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:33:14Z","timestamp":1495585994000},"page":"850-856","source":"Crossref","is-referenced-by-count":30,"title":["Stricter criteria for left bundle branch block diagnosis do not improve response to CRT"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-2904","authenticated-orcid":false,"given":"Emanuele","family":"Bertaglia","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baritussio","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Simone","sequence":"additional","affiliation":[{"name":"San Michele Clinic  Maddaloni CE Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino","family":"Reggiani","sequence":"additional","affiliation":[{"name":"Carlo Poma Hospital  Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pecora","sequence":"additional","affiliation":[{"name":"Fondazione Poliambulanza  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Monaldi Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rapacciuolo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Savarese","sequence":"additional","affiliation":[{"name":"Ospedale S. Giovanni Battista  Foligno PG Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Pierantozzi","sequence":"additional","affiliation":[{"name":"Ospedali Riuniti  Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biondino","family":"Marenna","sequence":"additional","affiliation":[{"name":"Ospedale degli Infermi  Biella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Ruffa","sequence":"additional","affiliation":[{"name":"Ospedale Manzoni  Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Campari","sequence":"additional","affiliation":[{"name":"Boston Scientific Italia  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Malacrida","sequence":"additional","affiliation":[{"name":"Boston Scientific Italia  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-0865","authenticated-orcid":false,"given":"Giuseppe","family":"Stabile","sequence":"additional","affiliation":[{"name":"Mediterranean Clinic  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_22_2_1","first-page":"e240","article-title":"American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. 2013 ACCF\/AHA Guideline for the Management of Heart Failure: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","author":"Yancy CW","year":"2013","journal-title":"Circulation."},{"key":"e_1_2_22_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_22_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.11.014"},{"key":"e_1_2_22_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000112"},{"key":"e_1_2_22_6_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000297"},{"key":"e_1_2_22_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-1268"},{"key":"e_1_2_22_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000140"},{"key":"e_1_2_22_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.05.020"},{"key":"e_1_2_22_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2012.09.001"},{"key":"e_1_2_22_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut132"},{"key":"e_1_2_22_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.04.005"},{"key":"e_1_2_22_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut049"},{"key":"e_1_2_22_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2012.03427.x"},{"key":"e_1_2_22_15_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3283644bb2"},{"key":"e_1_2_22_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq337"},{"key":"e_1_2_22_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191095"},{"key":"e_1_2_22_18_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2001.25652"},{"key":"e_1_2_22_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2015.01.008"},{"key":"e_1_2_22_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.90.1.44"},{"key":"e_1_2_22_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000850"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:29:17Z","timestamp":1696264157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,30]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/pace.13104"],"URL":"https:\/\/doi.org\/10.1111\/pace.13104","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,30]]}}}