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The catheter ablation of AF (AFCA) may cause the cardiac ANS dysfunction, whereas\u00a0restoration of sinus rhythm or sympathovagal imbalance by AFCA can\u00a0reverse this process. Our principal goal was to investigate the short\u2010term effect of AFCA on ANS functions evaluated by noninvasive chronotropic (CI), resting heart rate (RHR), and heart rate recovery (HRR) indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 45 patients were enrolled with symptomatic, drug refractory\u00a0paroxysmal AF undergoing first cryoballoon (CB) pulmonary vein antrum isolation (PVAI) with one 28\u2010mm CB using single 3\u2010minute freeze techniques without bonus applications. All patients underwent symptom\u2010limited exercise treadmill testing to evaluate noninvasive parameters of ANS before PVAI. For those patients who remained in sinus rhythm, an additional exercise test was repeated after 1 and 3 months after discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The autonomic CI and RHR\/HRR indices were impaired after PVAI and persisted post\u2010PVAI 3 months. However, these parameters were not different in patients with and without recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that the successful AFCA might concurrently impair the ANS parameters. The autonomic imbalance between the sympathetic and parasympathetic activity after AFCA could either become antiarrhythmic and\/or proarrhythmic based on which of the two components was going to prevail after successful AFCA. The impaired ANS balance after PVAI might also be another hypothetical mechanism for AF recurrence particularly in the absence of PV reconnection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13179","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T15:04:45Z","timestamp":1504019085000},"page":"1193-1199","source":"Crossref","is-referenced-by-count":14,"title":["The short\u2010term impact of the catheter ablation on noninvasive autonomic nervous system parameters in patients with paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"40","author":[{"given":"Mevlut Serdar","family":"Kuyumcu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital Health Sciences University  Ankara 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