{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:11:55Z","timestamp":1792671115556,"version":"4.5.0"},"reference-count":6,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ivabradine is a selective I<jats:italic><jats:sub>f<\/jats:sub><\/jats:italic>\u00a0channel blocker that reduces heart rate without affecting other cardiovascular functions. In case reports and case series, it was shown to improve symptoms in patients with postural tachycardia syndrome (POTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology and results<\/jats:title><jats:p>This retrospective study examined patients who were diagnosed with POTS and received ivabradine as part of their treatment. Forty\u2010nine patients (47 females, 95.9%) received ivabradine. The average age was 35.1 \u00b1 10.35 years. The most common symptoms were palpitations and lightheadedness and both improved significantly, 88.4% and 76.1% response rate, respectively. A total of 38 patients reported improvement in their symptoms. In addition, ivabradine resulted in an objective decrease in sitting and standing heart rate (78.1 \u00b1 10.7\u00a0vs 72.5 \u00b1 7.6, P\u2010value: 0.01) and (107.4 \u00b1 14.1\u00a0vs 95.1 \u00b1 13.7, P\u2010value:\u00a0&lt;\u00a00.001), respectively, with no significant change in blood pressure. The most common reported side effect was luminous phenomena\/visual brightness occurring in nine patients. However, none of the patients stopped ivabradine due to side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that ivabradine is likely to be effective in treating patients with POTS. Nearly 78% of our cohort reported a significant improvement in symptoms with no major adverse effects reported. A future randomized, placebo\u2010controlled trial is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13182","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T15:22:45Z","timestamp":1503933765000},"page":"1242-1245","source":"Crossref","is-referenced-by-count":43,"title":["Ivabradine in the treatment of postural tachycardia syndrome (POTS), a single center experience"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-8701","authenticated-orcid":false,"given":"Mohammed","family":"Ruzieh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Sirianni","sequence":"additional","affiliation":[{"name":"College of medicine University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Ammari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Dasa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luai","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Karabin","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Syncope and Autonomic Dysfunction Clinic University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Grubb","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Syncope and Autonomic Dysfunction Clinic University of Toledo  Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.761643"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.029"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq390"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut226"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10213"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-017-0225-y"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:11:23Z","timestamp":1695539483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,20]]},"references-count":6,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/pace.13182"],"URL":"https:\/\/doi.org\/10.1111\/pace.13182","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,20]]}}}