{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:46:24Z","timestamp":1780580784200,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Electrocardiogram abnormalities have been reported during electroconvulsive therapy (ECT). A corrected QT interval (QTc) prolongation indicates delayed ventricular repolarization, which can trigger ventricular arrhythmias such as torsade de pointes (TdP). We examined the QTc changes during generalized tonic\u2010clonic seizures induced by ECT, and the effects of atropine sulfate on these QTc changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed heart rate, QT interval, and QTc in 32 patients with depression who underwent ECT (25 women, 67.4 \u00b1 8.7 years of age). The QTc from \u221230 to 0 seconds prestimulation was used as baseline, which was compared with QTc at 20\u201330 seconds and 140\u2013150 seconds poststimulus onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QTc was significantly prolonged at 20\u201330 seconds poststimulus, then significantly decreased at 140\u2013150 seconds poststimulus, compared with baseline. QTc prolongation induced by ECT was significantly decreased by atropine sulfate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that the risk of TdP may be enhanced by ECT. Further, the risk of cardiac ventricular arrhythmias, including TdP, may be reduced by administration of atropine sulfate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13188","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T10:24:44Z","timestamp":1504261484000},"page":"1246-1253","source":"Crossref","is-referenced-by-count":5,"title":["Is prolongation of corrected QT interval associated with seizures induced by electroconvulsive therapy reduced by atropine sulfate?"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-1743","authenticated-orcid":false,"given":"Yoko","family":"Suzuki","sequence":"first","affiliation":[{"name":"Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Liaison 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