{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:02:19Z","timestamp":1768590139710,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Silent cerebral lesions (SCLs) are a potential complication of left atrial radiofrequency ablation (RFA) procedures for paroxysmal atrial fibrillation (PAF). We aimed to compare the incidence of SCLs in patients treated with irrigated RFA multielectrode catheters (nMARQ<jats:sup>\u00ae<\/jats:sup> Catheter group) and irrigated focal RFA catheters (NAVISTAR<jats:sup>\u00ae<\/jats:sup> THERMOCOOL<jats:sup>\u00ae<\/jats:sup> Catheter; TC group) after PAF ablation from subpopulation neurological assessment (SNA) cohorts of the REVOLUTION and reMARQable studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from SNA cohorts in the prospective, nonrandomized REVOLUTION study (March 2011\u2013September 2013) and the prospective, randomized, controlled reMARQable study (October 2013\u2013November 2015) were included. The incidence of SCLs was assessed pre\u2010 and postablation using magnetic resonance imaging. Neurological deficits were assessed using the National Institutes of Health Stroke Scale, modified Rankin Scale, and Montreal Cognitive Assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 patients from REVOLUTION and 76 patients from reMARQable were included in the SNA cohort of each study. In the REVOLUTION SNA cohort, the incidence of SCLs was 21.1% (4\/19) in the nMARQ<jats:sup>\u00ae<\/jats:sup> Catheter group and 5.9% (1\/17) in the TC group. Findings from REVOLUTION helped inform the reMARQable study protocol's stringent anticoagulation regimen. SCL incidence was subsequently reduced in both groups (nMARQ<jats:sup>\u00ae<\/jats:sup> Catheter, 7.9%; TC, 3.3%). No permanent neurological deficits were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adherence to a stringent anticoagulation regimen prior to and during ablation procedures appears to be an important factor in minimizing the risk of SCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13205","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T10:14:31Z","timestamp":1507112071000},"page":"1432-1439","source":"Crossref","is-referenced-by-count":10,"title":["Importance of anticoagulation and postablation silent cerebral lesions: Subanalyses of REVOLUTION and reMARQable studies"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-8884","authenticated-orcid":false,"given":"Massimo","family":"Grimaldi","sequence":"first","affiliation":[{"name":"Ospedale Generale \u201cF. Miulli,\u201d Acquaviva delle Fonti (Ba)  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Swarup","sequence":"additional","affiliation":[{"name":"Arizona Heart Rhythm Center  Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"DeVille","sequence":"additional","affiliation":[{"name":"Baylor Research Institute  Plano TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sussman","sequence":"additional","affiliation":[{"name":"Morristown Medical Center  Morristown NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Ja\u00efs","sequence":"additional","affiliation":[{"name":"CHU Bordeaux University of Bordeaux  IHU LIRYC ANR\u201010\u2010IAHU\u201004 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorenzo","family":"Gaita","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza di Torino, Medical Sciences Department University of Turin  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Duytschaever","sequence":"additional","affiliation":[{"name":"AZ St. Jan Cardiologie  Brugge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Andre","family":"Ng","sequence":"additional","affiliation":[{"name":"University of Leicester, NIHR Biomedical Research Centre Glenfield Hospital  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile","family":"Daoud","sequence":"additional","affiliation":[{"name":"Ohio State University Davis Heart and Lung Research Institute  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanunjaya (DJ)","family":"Lakkireddy","sequence":"additional","affiliation":[{"name":"University of Kansas Hospital Mid\u2010America Cardiology  KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Horton","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Research Foundation  TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wickliffe","sequence":"additional","affiliation":[{"name":"Piedmont Heart Institute  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Ellis","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-6360","authenticated-orcid":false,"given":"Laszlo","family":"Geller","sequence":"additional","affiliation":[{"name":"Semmelweis University Heart Center  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.937953"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02050.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-1368"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12736"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.04.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.06.030"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq303"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.11.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12500"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12151"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00279.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000612"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut250"},{"key":"e_1_2_8_18_1","first-page":"65","article-title":"Atrial fibrillation and silent stroke: links, risks, and challenges","volume":"12","author":"Hahne K","year":"2016","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02298.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32834ba0eb"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:18:29Z","timestamp":1695975509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/pace.13205"],"URL":"https:\/\/doi.org\/10.1111\/pace.13205","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}