{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:26:27Z","timestamp":1779236787103,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In longstanding persistent atrial fibrillation (LPeAF), the ideal endpoint of ablation remains to be determined. This study was to explore the value of pursuing AF termination or no with the same strategy during ablation on the long\u2010term outcomes in patients with LPeAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilized \u201cCCL\u201d strategy is a fixed ablation approach consisting of circumferential pulmonary vein antrum isolation, ablation of complex fractionated atrial electrogram, and linear ablation between two anatomical structures (the mitral isthmus, left atrial roof). Note that 400 patients were randomized to group A (technical endpoint) and group B (pursuing AF termination).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A group with technical endpoint had lower rate of acute AF termination (AF\u2192sinus rhythm, 3.5%\u00a0vs 18.1%; AF\u2192atrial tachycardia, 23.7%\u00a0vs 44.7%; P\u00a0&lt;\u00a00.01) and shorter duration of ablation (164.9 \u00b1 20.8\u00a0vs 223.4 \u00b1 24.9, P\u00a0&lt;\u00a00.01), radiofrequency delivery time (69.8 \u00b1 18.1\u00a0vs 102.2 \u00b1 26.3, P\u00a0&lt;\u00a00.01), and x\u2010ray exposure time (18.2 \u00b1 8.8\u00a0vs 27.9 \u00b1 12.4, P\u00a0&lt;\u00a00.01) than those in B group (pursuing AF termination). During follow\u2010up, freedom from atrial arrhythmias did\u00a0not\u00a0differ\u00a0between\u00a0the\u00a0two groups after a single ablation procedure (46.5%\u00a0vs 54.3%, P=0.12) and the final ablation procedure (60.1%\u00a0vs 65.8%, P\u00a0\u00a0=\u00a0\u00a00.24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients of LPeAF, pursuing AF termination during ablation was associated with similar long\u2010term clinical outcome compared to that with technical endpoint. Ablation to termination is not the best strategy during ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13221","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T04:22:40Z","timestamp":1507695760000},"page":"172-178","source":"Crossref","is-referenced-by-count":12,"title":["Optimal\u00a0endpoint for catheter ablation of longstanding persistent atrial fibrillation: A randomized clinical trial"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-5792","authenticated-orcid":false,"given":"Yuan\u2010long","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University  Shanghai 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