{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:38:37Z","timestamp":1770352717945,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T00:00:00Z","timestamp":1511049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Red cell distribution width (RDW) is a measure of the size variation of erythrocytes. Its prognostic value has been described in a variety of cardiac and noncardiac diseases. Implantable cardioverter defibrillator (ICD) is useful in preventing sudden cardiac death in high\u2010risk patients, but many of these patients continue to survive without needing ICD therapy. We sought to examine whether RDW, with its prognostic values, can benefit in risk stratification of patients with ICD by predicting death and ICD therapy, and thus help in the selection of patients who will benefit the most from ICD, and minimizing its implantation in others at low risk of death and arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study, we enrolled patients with ICD implanted for both primary and secondary prevention of sudden cardiac death. Baseline RDW values, demographics, and clinical characteristics, as well as the occurrence of death or first appropriate ICD therapy in postimplantation follow\u2010up were collected. We examined whether RDW can predict higher\u2010risk ICD\u2010implanted patients prone to death and first appropriate ICD therapy (the combined outcome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final population included 432 patients. Compared to others, patients in the upper RDW tertile were older and had more comorbidities and outcomes. In multivariate analysis including RDW, age, gender, and ejection fraction, RDW was the only predictor of the combined outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RDW may be useful in risk stratification of patients selected for ICD implantation. But larger prospective randomized trials are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13226","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T02:22:38Z","timestamp":1508898158000},"page":"1384-1388","source":"Crossref","is-referenced-by-count":2,"title":["Red cell distribution width predicts death and appropriate therapy in patients with implantable cardioverter defibrillator: A simple measurement with prognostic value in a variety of diseases, may help in better selection of patients who will benefit the most from this device"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-9763","authenticated-orcid":false,"given":"Saleem","family":"Dabbah","sequence":"first","affiliation":[{"name":"Cardiology Department Ziv Medical Center  Safed Israel"},{"name":"Faculty of Medicine in the Galilee Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Chertin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in the Galilee Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aehab","family":"Khateeb","sequence":"additional","affiliation":[{"name":"Cardiology Department Ziv Medical Center  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Cardiology Department Ziv Medical Center  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Suleiman","sequence":"additional","affiliation":[{"name":"Cardiology Department Rambam Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majdi","family":"Halabi","sequence":"additional","affiliation":[{"name":"Cardiology Department Ziv Medical Center  Safed Israel"},{"name":"Faculty of Medicine in the Galilee Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.992064"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-1152"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-012-9694-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0588-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.926771"},{"key":"e_1_2_8_7_1","first-page":"145619","article-title":"Elevated red blood cell distribution width as a simple prognostic factor in patients with symptomatic multiple myeloma","volume":"2014","author":"Lee H","year":"2014","journal-title":"Biomed Res 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