{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:03:19Z","timestamp":1770897799093,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study deals with clinical and echocardiographic outcomes in cardiac resynchronization therapy (CRT) nonresponders patients undergoing Mitraclip procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Functional mitral regurgitation (FMR) occurs in approximately one\u2010third of heart failure (HF) patients. Resynchronization therapy may correct FMR in patients with HF; however, significant FMR persists in 20\u201325% of CRT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients included were previously treated with CRT for at least 6 months and remained classified as New York Heart Association (NYHA) functional class III or IV despite optimal medical therapy; the echocardiographic assessment showed lack of decrease of the left ventricular end\u2010systolic volume (LVESV) of at least 10% and residual moderate\u2010to\u2010severe or severe FMR. Clinical and echocardiographic follow\u2010up was scheduled at 1, 3, 6, and 12 months after Mitraclip implantation, and every 6 months thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients fulfilled inclusion criteria. Before Mitraclip implantation NYHA class was III in 83% and IV in 17% of patients; after CRT no patient experienced an improvement in FMR. There was a significant improvement in NYHA class from baseline to 6 months, which remained sustained at 12 and 24 months. The degree of FMR significantly improved from baseline to 6 months and from 6 to 12 months. There was left ventricle remodeling with significant reduction of LVESV and an increase of left ventricle ejection fraction at 6 and 12 months, while the opposite trend was noted between 12 and 24 months<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of moderate to severe FMR in CRT nonresponder is feasible, safe, and reasonably effective in reducing cardiac symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13241","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T13:22:36Z","timestamp":1510752156000},"page":"65-72","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term clinical and echocardiographic outcomes of Mitraclip therapy in patients nonresponders to cardiac resynchronization"],"prefix":"10.1111","volume":"41","author":[{"given":"Valerio L.","family":"Giaimo","sequence":"first","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-5353","authenticated-orcid":false,"given":"Paolo","family":"Zappulla","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Cirasa","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Tempio","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Rapisarda","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Trovato","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Di","family":"Grazia","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Liotta","sequence":"additional","affiliation":[{"name":"Arrhythmology OU, Ferrarotto Hospital University of Catania  Catania 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