{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:36:13Z","timestamp":1761863773513,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effects of cardiac resynchronization therapy (CRT) on secondary mitral regurgitation (MR), and mitral valve (MV) and left ventricular (LV) geometry, in patients with prior inferior myocardial infarction is not clearly defined. We assessed these outcomes utilizing two\u2010dimensional echocardiography, and analyzed echocardiographic geometric variables that may correlate with follow\u2010up MR severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2009 and 2012, 229 CRT were implanted. Twenty\u2010two had prior inferior myocardial infarction, \u2265mild MR at baseline, and serial echocardiography. A left bundle branch block was present in 12 (54.5%) patients. The pre\u2010CRT and follow\u2010up echocardiograms were analyzed for: (1) MR severity; (2) MV and LV geometry; and (3) LV remodeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 2.2 years (interquartile range, 0.7\u20134). In 16 patients without an inferior myocardial scar, there was a reduction in MR jet area\/left atrial area ratio (33.2%\u00a0vs 25.8%; P\u00a0=\u00a00.06) and MR grade (2.3\u00a0vs 1.8; P\u00a0=\u00a00.05), and an increased LV ejection fraction (26.1%\u00a0vs 30.9%; P\u00a0=\u00a00.04) and end\u2010systolic posterior ventricular sulcus\u2010anterolateral papillary muscle angle (133.9\u00a0vs 143.9 degrees; P\u00a0=\u00a00.01). In six patients with scar, there was no change in LV or MR parameters. Regression analysis revealed linear associations between baseline MV tenting height (r\u00a0=\u00a00.57; P\u00a0=\u00a00.006), LV end\u2010diastolic diameter index (r\u00a0=\u00a00.5; P\u00a0=\u00a00.02), mitral septolateral annular diameter (r\u00a0=\u00a00.48; P\u00a0=\u00a00.03), and MV tenting area (r\u00a0= 0.46; P = 0.03), with follow\u2010up MR jet area\/left atrial area ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with prior inferior myocardial infarction and no scar, CRT is associated with decreased MR severity, and improved papillary muscle alignment and LV systolic function at follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13255","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T10:53:15Z","timestamp":1512816795000},"page":"114-121","source":"Crossref","is-referenced-by-count":2,"title":["Effects of cardiac resynchronization therapy after inferior myocardial infarction on 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