{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:01:51Z","timestamp":1758394911827,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001857"],"award-info":[{"award-number":["UL1\u2010TR\u2010001857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Successful ablation sites in Wolff\u2010Parkinson\u2010White syndrome (WPW) are characterized by short atrioventricular (AV) intervals. Approximately 15% of patients with WPW have adenosine\u2010sensitive accessory pathways (APs). We sought to determine if local AV intervals of adenosine\u2010sensitive APs are different from those of adenosine\u2010insensitive APs in patients with WPW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients \u226421 years with WPW and adenosine\u2010sensitive APs who underwent successful ablation over a 9\u2010year period were included. Patients with WPW and adenosine\u2010insensitive APs were matched by age and weight in a 1:2 case\u2010control design. AP location, antegrade and retrograde conduction properties, supraventricular tachycardia (SVT) inducibility, local AV interval, interval from delta wave onset to local ventricular activation (del\u2010V), and time to loss of preexcitation were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen patients with adenosine\u2010sensitive APs and 28 with adenosine\u2010insensitive APs were included. Patients with adenosine\u2010sensitive APs had minimum 1:1 antegrade AP conduction at a longer median paced cycle length (380, interquartile range [IQR] 295 to 585\u00a0ms vs 290, IQR 250 to 330\u00a0ms, P\u00a0=\u00a00.046), were less likely to have inducible SVT (35.7%\u00a0vs 75.0%, P\u00a0=\u00a00.035), and had a longer median local AV interval (40.5, IQR 30.8 to 58.3\u00a0ms vs 32.0, IQR 29.3 to 37.8\u00a0ms, P\u00a0=\u00a00.029) when compared to those with adenosine\u2010insensitive APs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with WPW and adenosine\u2010sensitive APs have 1:1 antegrade AP conduction at longer cycle lengths, lower likelihood of SVT induction, and longer local AV intervals when compared to those with adenosine\u2010insensitive APs. In patients with WPW, it may be important to consider adenosine response when selecting appropriate ablation targets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13257","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T10:52:52Z","timestamp":1512816772000},"page":"35-41","source":"Crossref","is-referenced-by-count":5,"title":["Adenosine\u2010sensitive Wolff\u2010Parkinson\u2010White: Longer time across the atrioventricular groove"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-3001","authenticated-orcid":false,"given":"Cheyenne","family":"Beach","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1029-800X","authenticated-orcid":false,"given":"Christopher W.","family":"Follansbee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Beerman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Mazzocco","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Institute University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.3.866"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.035"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12623"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1499"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002140"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80782-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12324"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12089"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1198\/106186006X137047"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.884"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.02.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a061827"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:08:18Z","timestamp":1695884898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/pace.13257"],"URL":"https:\/\/doi.org\/10.1111\/pace.13257","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}