{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:38:31Z","timestamp":1785033511510,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cryoballoon (CB) applications to pulmonary veins (PVs) can cause stenosis just as radiofrequency (RF) energy deliveries. The goal of the present study was to clarify whether or not there was any difference in the extent of acute or chronic PV narrowing after PV isolation between the two different energy sources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with paroxysmal atrial fibrillation who were scheduled to undergo a PV isolation were randomized 1:1 to receive CB or RF ablation. The endpoints were any acute PV narrowing assessed with the use of intracardiac ultrasound during the procedure and PV stenosis measured with cardiac computed tomography at the 3\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An acute reduction in the luminal area of the left superior PV (mean \u00b1 standard deviation, \u20136.8 \u00b1 8.7\u00a0vs \u201319.9 \u00b1 14.7%; P\u00a0&lt;\u00a00.001) and left inferior PV (\u20135.1 \u00b1 20.2\u00a0vs \u201315.3 \u00b1 11.6%; P\u00a0=\u00a00.03) was significantly smaller in the CB arm (N\u00a0=\u00a025) than the RF arm (N\u00a0=\u00a025). There was no difference in the extent of PV stenosis 3 months after the ablation between the arms (0\u201325% stenosis, 90%\u00a0vs 88%, 25\u201350% stenosis, 10%\u00a0vs 12%,\u00a0&gt;50% stenosis, both 0%; P\u00a0=\u00a00.82). A greater acute PV narrowing was likely to lead to chronic stenosis in the RF arm (P\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CB ablation may reduce the acute narrowing of the left\u2010sided PVs as compared to RF ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13293","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T08:52:35Z","timestamp":1517302355000},"page":"376-382","source":"Crossref","is-referenced-by-count":17,"title":["Head\u2010to\u2010head comparison of acute and chronic pulmonary vein stenosis for cryoballoon versus radiofrequency ablation"],"prefix":"10.1111","volume":"41","author":[{"given":"Ryo","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"},{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-1508","authenticated-orcid":false,"given":"Akinori","family":"Sairaku","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Nanasato","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuho","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monami","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"},{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-5672","authenticated-orcid":false,"given":"Yasuya","family":"Inden","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya 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