{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:32:32Z","timestamp":1740137552133,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary vein isolation (PVI) is a well\u2010established method for the treatment of symptomatic paroxysmal atrial fibrillation, but is only partly successful with a high rate of electrical reconnection. We introduce a novel technique in which PVI is accomplished by noninvasive heating of a dedicated thermoresponse implant inserted into the pulmonary veins (PV), demonstrated in a porcine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A self\u2010expanding nitinol\u2010based implant was positioned in the common inferior PV of 11 pigs, using a fluoroscopy\u2010guided transatrial appendage approach. Ablation was performed through contactless energy transfer from a primary extracorporal coil to a secondary heat ring (HR) embedded in the proximal part of the implant. Electrophysiological conduction was assessed prior to and postablation, and at 3 months. Histological samples were obtained acutely (n\u00a0\u00a0=\u00a0\u00a04) and after 3 months (n\u00a0\u00a0=\u00a0\u00a07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 13 PV implants were successfully positioned in the inferior PVs of 11 animals. Ablation was performed without injury of adjacent structures. PVI and bidirectional block was electrophysiologically confirmed in all cases immediately at the time of implantation and 3 months later in seven chronic animals in whom testing was repeated. Marked evidence of ablation around the proximal HR was evident at 3 months postprocedure, with scar tissue formation and only mild neointimal proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Successful PVI can be obtained by external electromagnetic heat transfer to a novel pulmonary vein implant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13345","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T22:59:23Z","timestamp":1523401163000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer: Evaluation in a porcine model"],"prefix":"10.1111","volume":"41","author":[{"given":"Tim","family":"Boussy","sequence":"first","affiliation":[{"name":"Department of Cardiology AZ Groeninge Kortrijk\/AZM Middelares  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-3702","authenticated-orcid":false,"given":"Tim","family":"Vandecasteele","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisse","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Schauvliege","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anesthesia of Domestic Animals Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Philpott","sequence":"additional","affiliation":[{"name":"Fulgur Medical  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Clement","sequence":"additional","affiliation":[{"name":"Fulgur Medical  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther","family":"van Loon","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udi","family":"Willenz","sequence":"additional","affiliation":[{"name":"Lahav CRO Laboratory of Preclinical Services  Kibbutz Lahav Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[{"name":"CRF\u2010Skirball Center for Innovation  Orangeburg NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation Columbia University  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek Y.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Center Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Van Langenhove","sequence":"additional","affiliation":[{"name":"Fulgur Medical  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004549"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001346"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.40680.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv139"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-11-2-71"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003337"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2015-000257"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.986465"},{"key":"e_1_2_6_13_1","first-page":"12631","article-title":"Percutaneous transapical access for pulmonary vein mapping and ablation in a porcine model with a new high\u2010density electroanatomical mapping system","volume":"8","author":"Bollmann A","year":"2015","journal-title":"Int J Clin Exp Med"}],"container-title":["Pacing and Clinical 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