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BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. Despite over 25 years of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still rapidly evolving. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular, and genetic mechanisms underlying these two syndromes that have captured the interest and attention of the cardiology community over the past two decades.<\/jats:p>","DOI":"10.1111\/pace.13408","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T13:22:32Z","timestamp":1528204952000},"page":"684-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["J wave syndromes as a cause of malignant cardiac arrhythmias"],"prefix":"10.1111","volume":"41","author":[{"given":"Jos\u00e9 M.","family":"Di Diego","sequence":"first","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-1582","authenticated-orcid":false,"given":"Charles","family":"Antzelevitch","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood PA USA"},{"name":"Lankenau Heart Institute Wynnewood PA USA"},{"name":"Sidney Kimmel Medical College of Thomas Jefferson University Philadelphia PA 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