{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:24:24Z","timestamp":1762507464692,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incorporation of QTc in clinical decision support systems requires accurate QT\u2010interval correction, also during common electrocardiogram abnormalities as ventricular conduction defects (VCD). We compared the performance and predictive value of QT correction formulas to design a patient\u2010specific QT correction algorithm (QTcA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The first ECG in adult patients with sinus rhythm (SR), atrial fibrillation (AF), and ventricular pacing (VP) was collected retrospectively. QT correction was performed with Bazett (QTcB), Fridericia (QTcFri), Framingham, Hodges, and Rautaharju (QTcR) formulas. Correction formulas were compared using QTc\/RR linear regression. Adjusted Cox regression was performed to predict 1\u2010year all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49,737 patients were included (70.0% SR, 24.1% AF, 5.9% VP, 11.1% VCD). Overall 1\u2010year all\u2010cause mortality rate was 11.8%.<\/jats:p><jats:p>In patients without VCD or VP, QTcFri showed significantly better heart rate correction, both overall (P\u00a0&lt;\u00a00.001) and in subgroups by heart rate (bradycardia P\u00a0\u2264\u00a00.001, normal P\u00a0\u2264\u00a00.050, tachycardia P\u00a0\u2264\u00a00.010). Furthermore, QTcFri improved mortality prediction significantly when compared to QTcB (P\u00a0&lt;\u00a00.001). Patients with VCD or VP QTcR, including correction for QRS duration, had a significant better heart rate correction than QTcB (P\u00a0\u2264\u00a00.010) and improved mortality prediction significantly compared to all other formulas (P\u00a0&lt;\u00a00.001). Implementing QTcA, designed based on QTcFri and QTcR depending on the presence of VCD or VP, reduced the patients considered to be at risk by 61.1% when compared to QTcB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A patient\u2010specific QT correction algorithm would combine accurate heart rate correction, improved predictive value of mortality, and a reduction of patients considered to be at risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13423","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T16:28:25Z","timestamp":1529598505000},"page":"1101-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["QT correction across the heart rate spectrum, in atrial fibrillation and ventricular conduction defects"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-920X","authenticated-orcid":false,"given":"Bert","family":"Vandenberk","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline","family":"Vandael","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Robyns","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Garweg","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Foulon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Ector","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven 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