{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:32:38Z","timestamp":1740137558546,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medtronic Hellas SA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial appendage (LAA) functional modification in the context of pulmonary vein isolation has been a focus point of research and LAA emptying flow velocity (LAAEFV) is considered to reflect LAA contractility, stunning, and fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In the present study, we sought to prospectively evaluate short\u2010term LAAEFV changes after radiofrequency (RF) or cryoballoon ablation in paroxysmal AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective substudy of the Effect of Cryoballoon and RF Ablation on Left Atrial Function (CryoLAEF) study (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier: NCT02611869). Thirty patients, randomly assigned to RF or cryoablation, were prospectively followed. Transesophageal echocardiograms were performed at baseline and at 3 months postablation to measure LAAEFV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All measurements were performed in sinus rhythm. Overall, LAAEFV was 44.2 [38.5\u201362.8] cm\/s at baseline and was increased to 70.8 [64.8\u201377.6] cm\/s at 3 months\u2019 postablation (P\u00a0&lt;\u00a00.001). Baseline LAAEFV was 52.5 [37.7\u201368.0] cm\/s in the RF group and 42.8 [38.7\u201352.9] cm\/s in the CryoBalloon group (P\u00a0\u00a0=\u00a0\u00a00.653). At 3 months, the corresponding values were 68.5 [61.9\u201376.6] cm\/s and 73.9 [69.2\u201379.9] cm\/s, respectively (P\u00a0\u00a0=\u00a0\u00a00.081 for the difference between the two groups at 3 months). The median change in LAAEFV was 11.0 [4.7\u201326.2] cm\/s in the RF group versus 29.6 [15.8\u201337.0] cm\/s in the CryoBalloon group (P\u00a0\u00a0=\u00a0\u00a00.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LAA function is improved after catheter ablation with RF or balloon cryoablation in patients with paroxysmal AF, evaluated while in sinus rhythm both at baseline and on follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13436","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T09:42:00Z","timestamp":1532079720000},"page":"1129-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of pulmonary vein isolation on left atrial appendage flow in paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-3850","authenticated-orcid":false,"given":"Georgios","family":"Giannopoulos","sequence":"first","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"},{"name":"2nd Department of Cardiology National and Kapodistrian University of Athens Medical School  Attikon Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Kekeris","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Vrachatis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Kossyvakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Ntavelas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tsitsinakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Koutivas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Tolis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Angelidis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Deftereos","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology National and Kapodistrian University of Athens Medical School  Attikon Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00956.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01071.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-016-0216-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.116826"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.10.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(99)70105-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.68"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.02.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011656"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12710"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01800-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.04.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12823"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.13-370"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1518"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2012.09.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5152\/AnatolJCardiol.2015.6309"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.446"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/eux151.083"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.11.009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12143"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12241"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01431.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.05.006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.11.058"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-016-0819-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.02.020"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.07.002"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:11:03Z","timestamp":1694981463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/pace.13436"],"URL":"https:\/\/doi.org\/10.1111\/pace.13436","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"assertion":[{"value":"2017-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}