{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:41:21Z","timestamp":1776400881727,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients requiring cardiac implantable electronic device (CIED) implantation are on long\u2010term oral anticoagulant therapy. While continuation of warfarin has been shown to be safe and reduce bleeding complications compared to interruption of warfarin therapy and heparin bridging, it is not known which novel oral anticoagulants (NOAC) regimen (interrupted vs uninterrupted) is better in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred and one patients were randomized to receive CIED implantation with either interrupted or uninterrupted\/continuous NOAC therapy before surgery. No heparin was used in either treatment arm. The primary end\u2010point was the presence of a clinically significant pocket hematoma after CIED implantation. The secondary end\u2010point was a composite of other major bleeding events, device\u2010related infection, thrombotic events, and device\u2010related admission length postdevice implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatment groups were equally balanced for baseline variables and concomitant medications. One clinically significant pocket hematoma occurred in the uninterrupted NOAC group and none in the interrupted group (P\u00a0\u00a0=\u00a0\u00a00.320). There was no difference in other bleeding complications. No thrombotic events were observed in either of the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the paucity of bleeding events, data from this pilot study suggest that uninterrupted NOAC therapy for CIED implantation appears to be as safe as NOAC interruption and does not increase bleeding complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13482","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:41:35Z","timestamp":1534956095000},"page":"1476-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Interrupted versus uninterrupted novel oral anticoagulant peri\u2010implantation of cardiac device: A single\u2010center randomized prospective pilot trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Danilo","family":"Ricciardi","sequence":"first","affiliation":[{"name":"Campus Bio\u2010Medico Unit of Cardiology University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7743-0143","authenticated-orcid":false,"given":"Antonio","family":"Creta","sequence":"additional","affiliation":[{"name":"Campus Bio\u2010Medico Unit of Cardiology University of Rome  Rome Italy"},{"name":"Barts Heart Centre St. Bartholomew's Hospital  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iginio","family":"Colaiori","sequence":"additional","affiliation":[{"name":"Campus Bio\u2010Medico Unit of Cardiology University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Scordino","sequence":"additional","affiliation":[{"name":"Campus Bio\u2010Medico Unit of Cardiology University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ragni","sequence":"additional","affiliation":[{"name":"Campus Bio\u2010Medico Unit of 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