{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:34:17Z","timestamp":1778286857613,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to evaluate a spatial correlation between active atrial fibrillation (AF) drivers measured by electrocardiographic imaging and complex fractionated atrial electrograms (CFAEs) in patients with persistent AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients with persistent AF were included. A biatrial geometry relative to an array of 252\u2010body\u2010surface\u2010electrodes was obtained from a noncontrast computed tomography scan. The reconstructed unipolar AF electrograms were signal\u2010processed (ECVUE\u2122, CardioInsight Technologies Inc., Cleveland, OH, USA) to identify AF drivers. Before driver ablation, a biatrial mapping using the NavX system (St. Jude Medical, St. Paul, MN, USA) was performed to identify CFAEs. CFAE and driver regions were then quantified and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AF was terminated by driver ablation in 11\/16 (70%) patients. The mean number of ablated driver regions was 4\u00a0\u00b1\u00a01 per patient. The most frequent driver locations were the inferior left atrium and coronary sinus, the right pulmonary veins, and the right atrium. In 49\/63 (78%) of the driver locations, more than 75% of the driver site showed CFAEs. The mean ablated driver area was 58\u00a0\u00b1\u00a024\u00a0cm<jats:sup>2<\/jats:sup> (19\u00a0\u00b1\u00a011% of total surface area). The mean CFAE area was 178\u00a0\u00b1\u00a059\u00a0cm<jats:sup>2<\/jats:sup> (49\u00a0\u00b1\u00a016%). The percentage of non\u2010ablated CFAE area was 76\u00a0\u00b1\u00a013% of total CFAEs. In 9\/11 patients with AF termination, the termination site showed CFAEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a significant overlap between AF driver regions identified by the ECVUE\u2122 system and CFAE areas identified by the NavX system. AF driver regions are smaller and mostly embedded in larger CFAE areas. Selective ablation of drivers in CFAE areas seems sufficient to terminate persistent AF in the majority of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13483","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T17:43:32Z","timestamp":1534959812000},"page":"1279-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Correlation between atrial fibrillation driver locations and complex fractionated atrial electrograms in patients with persistent atrial fibrillation"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0123-7213","authenticated-orcid":false,"given":"Sonia","family":"Ammar\u2010Busch","sequence":"first","affiliation":[{"name":"Klinikum Coburg  Coburg Germany"},{"name":"Department of Electrophysiology, Deutsches Herzzentrum M\u00fcnchen Technische Universitaet  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilko","family":"Reents","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Deutsches Herzzentrum M\u00fcnchen Technische Universitaet  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Knecht","sequence":"additional","affiliation":[{"name":"AZ Sint\u2010Jan  Bruges Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Rostock","sequence":"additional","affiliation":[{"name":"Johannes Gutenberg\u2010University Mainz University Hospital  II. Medical Clinic Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Arentz","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts\u2010Herzzentrum Freiburg\u2010Bad Krozingen  Bad Krozingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Duytschaever","sequence":"additional","affiliation":[{"name":"AZ Sint\u2010Jan  Bruges Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Neumann","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Cauchemez","sequence":"additional","affiliation":[{"name":"Clinique Ambroise Par\u00e9  Neuilly\u2010sur\u2010Seine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Albenque","sequence":"additional","affiliation":[{"name":"Clinique Pasteur  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Hessling","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Deutsches Herzzentrum M\u00fcnchen Technische Universitaet  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Deisenhofer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Deutsches Herzzentrum M\u00fcnchen Technische Universitaet  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/europace\/eum120","article-title":"HRS\/EHRA\/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for personnel, policy, procedures and follow\u2010up. 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