{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T14:14:57Z","timestamp":1780841697311,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cefazolin is used as standard preoperative prophylaxis for a variety of surgical procedures that involve the skin. In contrast, vancomycin is recommended for a minority of patients, specifically those with an IgE\u2010mediated allergy to beta\u2010lactams and considered in patients with known colonization with methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> or at high risk for such. Vancomycin, however, has been overprescribed, has nephrotoxicity risk, and may be less effective due to its inferior coverage of methicillin\u2010susceptible <jats:italic>S. aureus<\/jats:italic> and lack of Gram\u2010negative coverage. This study was performed to assess whether vancomycin use was associated with an increased incidence of cardiovascular implantable electronic device infection (CIEDI) as compared to that of cefazolin or other antistaphylococcal beta\u2010lactam antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The VA Informatics and Computing Infrastructure database, which included all veterans who underwent CIED placement or revision between 2008 and 2015, was used. A logistic regression model was constructed to estimate the adjusted odds of CIEDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 10,454 CIED procedures were included, and 98% of them were performed in men with a mean age of 71 \u00b1 12 years. The logistic regression analysis showed that vancomycin use alone or in combination with other antibiotics was associated with an increased risk of CIEDI (odds ratio 2.99 [1.76\u20135.06], P\u2010value\u00a0&lt;\u00a00.001), after controlling for other effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study revealed that among patients who received surgical site infection prophylaxis for CIED placement or revision, there was: (1) an unanticipated high rate of vancomycin use, and (2) a threefold increase in the incidence of subsequent CIEDI among vancomycin recipient<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13499","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T07:25:21Z","timestamp":1537169121000},"page":"1513-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preoperative antibiotics and cardiovascular implantable electronic device infection: A cohort study in veterans"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-4059","authenticated-orcid":false,"given":"Talal","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Medical Service Washington DC VA Medical Center  Washington DC USA"},{"name":"Department of Medicine George Washington University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelike P.","family":"Liappis","sequence":"additional","affiliation":[{"name":"Medical Service Washington DC VA Medical Center  Washington DC USA"},{"name":"Department of Medicine George Washington University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry M.","family":"Baddour","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Cardiovascular Medicine, Division of Infectious Diseases Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela E.","family":"Karasik","sequence":"additional","affiliation":[{"name":"Medical Service Washington DC VA Medical Center  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.8.2098"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.033"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.795906"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00294.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1984.tb05626.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678664"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/518889"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.18.1796"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv053"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.4.339"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192665"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.9999"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32832b3585"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.01.019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.01.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.11.1348"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1182"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/430910"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/383318"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.11.1831"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018816638223"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-4062-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-279"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ308"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-016-0143-3"},{"key":"e_1_2_7_27_1","unstructured":"JohnJF DavidsonRJ LowDE.Staphylococcus epidermidisand other coagulase\u2010negative staphylococci. 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