{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:25:20Z","timestamp":1777429520827,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Atrial fibrosis is associated with the pathogenesis and progression of atrial fibrillation (AF). We sought to evaluate the extent of left atrial (LA) scarring in patients with paroxysmal AF (PAF) undergoing catheter ablation using a new impedance\u2010based algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled 73 consecutive patients (43 males, 58 years) with PAF who underwent pulmonary vein antral isolation. We first performed high\u2010density bipolar voltage mapping during sinus rhythm using Tissue Proximity Indicator (TPI), one of the features of the ConfiDense mapping module integrated in the electroanatomic mapping system. A dense LA shell was created initially without TPI (mean points 2,411) and subsequently activating TPI (mean points 1,167). Each point was classified according to the peak\u2010to\u2010peak bipolar voltage electrogram based on two criteria (criterion A: healthy\u00a0&gt;0.8\u00a0mV, border zone: 0.4\u20130.8\u00a0mV, scarred:\u00a0&lt;0.4\u00a0mV; criterion B: healthy:\u00a0&gt;0.5\u00a0mV, border zone: 0.25\u20130.5\u00a0mV, scarred:\u00a0&lt;0.25\u00a0mV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LA voltage analysis represented significantly smaller scarred areas when mapping was performed with TPI\u2010ON compared with TPI\u2010OFF in both voltage criteria (average LA voltage area: 3.02 \u00b1 5.28 cm<jats:sup>2<\/jats:sup> vs 9.15 \u00b1 13.11 cm<jats:sup>2<\/jats:sup> vs in criterion A and 1.19 \u00b1 2.54 cm<jats:sup>2<\/jats:sup> vs 5.61 \u00b1 9.56 cm<jats:sup>2<\/jats:sup> in criterion B). A statistically significant voltage difference was observed in all segments of the left atrium between the two mapping protocols, particularly on the inferior wall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A more specific delineation of LA fibrosis may be produced using the TPI feature of the ConfiDense mapping module, through elimination of false\u2010positive annotated mapping points due to low contact.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13501","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T05:29:13Z","timestamp":1537248553000},"page":"1447-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Left atrial voltage mapping using a new impedance\u2010based algorithm in patients with paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-8983","authenticated-orcid":false,"given":"Dimitrios","family":"Asvestas","sequence":"first","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Vlachos","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Bazoukis","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Papworth Hospital NHS Foundation Trust  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-8261","authenticated-orcid":false,"given":"Konstantinos P.","family":"Letsas","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antigoni","family":"Sakellaropoulou","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Kossyvakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u201cG. Gennimatas\u201d General Hospital of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Saplaouras","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathia","family":"Prappa","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Goga","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios","family":"Vassilikos","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology, Hippokration Hospital, Medical School Aristotle University of Thessaloniki  Thessaloniki 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