{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T17:38:55Z","timestamp":1774719535585,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implantable cardioverter defibrillator (ICD) offers an opportunity to examine vulnerability to ventricular tachycardia (VT) or ventricular fibrillation (VF) by performing noninvasive programmed ventricular stimulation (NIPS). Whether NIPS can predict VT\/VF recurrences has not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the predictive value of NIPS for identification of patients with VT\/VF recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group consisted of consecutive 105 ICD recipients included in the prospective NIPS\u2010ICD study (ClinicalTrials ID: NCT02373306) (88 males, age 65\u00a0\u00b1\u00a011\u00a0years). The patients\u00a0underwent NIPS using the protocol up to three premature extrastimuli at 600\u2013500\u2010 and 400\u2010ms drive cycle lengths. The endpoint of NIPS was induction of sustained VT or VF or completion of the protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VT\/VF was induced in 29 (27.6%) patients. During a 12\u2010month follow\u2010up NIPS\u2010inducible patients had significantly more frequently appropriate ICD therapy than noninducible patients (17%\u00a0vs 4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023). NIPS\u2010induced VT\/VF had a sensitivity of 63%, specificity of 75%, positive predictive value of 17%, and negative predictive value of 96% for identification of patients with future VT\/VF. Apart from NIPS, age \u2265\u00a065\u00a0years, QRS duration, treatment with angiotensin\u2010converting enzyme, history of coronary artery bypass grafting, history of VT\/VF prior to NIPS, and prior appropriate ICD therapy were also associated with VT\/VF recurrences. Multivariate analysis showed that, together with QRS duration, NIPS result was an independent predictor of future VT\/VF. Predictive value of NIPS was significantly higher in ischemic than nonischemic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NIPS result is associated with future VT\/VF. Noninducibility at NIPS identifies those patients with high accuracy who will have uneventful follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13523","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T09:10:05Z","timestamp":1539162605000},"page":"1643-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of noninvasive programmed stimulation in patients with implantable cardioverter defibrillator"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-4066","authenticated-orcid":false,"given":"Piotr","family":"Futyma","sequence":"first","affiliation":[{"name":"Invasive Cardiology Department St. Joseph's Heart Center  Rzesz\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Sander","sequence":"additional","affiliation":[{"name":"Invasive Cardiology Department St. 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