{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:56:06Z","timestamp":1772826966785,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite available evidence that implantable cardioverter defibrillators (ICDs) reduce all\u2010cause mortality among patients at risk for sudden cardiac death, utilization of ICDs is low especially in developing countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To summarize reasons for ICD or cardiac resynchronization therapy defibrillator implant refusal by patients at risk for sudden cardiac arrest (Improve SCA) in developing countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Primary prevention (PP) and secondary prevention (SP) patients from countries where ICD use is low were enrolled. PP patients with additional risk factors (syncope, ejection fraction\u00a0&lt;\u00a025%, nonsustained ventricular tachycardia [NSVT], or frequent premature ventricular complexes) were further categorized as \u201c1.5 PP patients.\u201d Candidates who declined implantation were asked for reasons for refusal. Baseline factors that may have influenced the implant decision were examined using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3892 patients, the implant refusal rate was 46.5% among PP patients (<jats:italic>n<\/jats:italic> = 2700), and 10.3% among SP patients (<jats:italic>n<\/jats:italic> = 1192). The most common refusal reason was inability to pay for the device (53.8%), followed by not believing in the benefits of the ICD (19.4%). Among PP ICD candidates, those with no syncope, no NSVT, no premature ventricular contractions, shorter QRS duration, no atrial arrhythmias, and no left bundle branch block were more likely to refuse implant. Among SP candidates, a history of cardiovascular surgery and no sinus node dysfunction were significant predictors of ICD refusal. Additionally, countries had significant differences in patient refusal rates among PP and SP groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implant refusal among PP patients is high in many countries. Increased reimbursement and better awareness of the benefits of an ICD could increase their utilization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13526","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T10:13:51Z","timestamp":1539598431000},"page":"1619-1626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improving the utilization of implantable cardioverter defibrillators for sudden cardiac arrest prevention (Improve SCA) in developing countries: Clinical characteristics and reasons for implantation refusal"],"prefix":"10.1111","volume":"41","author":[{"given":"Balbir","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medanta The Medicity Hospital  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center Fuwai Cardiovascular Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Keong","family":"Ching","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Heart Centre of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto de Cardiolog\u00eda, Fundaci\u00f3n Cardio infantil, Centro Internacional de Arritmias Bogota, Colombia and Universidad de la Sabana  Ch\u00eda 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