{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:50:38Z","timestamp":1747187438471,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A high burden of ventricular premature depolarizations (VPDs) has been associated with potentially reversible left ventricular (LV) dysfunction, termed as VPD\u2010induced cardiomyopathy (CMP). However, many patients maintain normal LV function despite a high VPD burden. The purpose of this study was to identify CMP by right ventricle apex (RVa) pacing method in patients with high VPD burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 62 patients (28 male; mean age\u00a0=\u00a050\u00a0\u00b1\u00a015\u00a0years) with idiopathic VPDs undergoing ablation were enrolled. RVa pacing was recorded in all patients during the procedure. The paced QRS duration (QRSd) during RV pacing was measured from the pacing spike to the latest QRS deflection on any surface electrocardiogram lead. Patients were divided into two groups: reversible VPD\u2010induced CMP (Group R; <jats:italic>n<\/jats:italic> \u00a0=\u00a015, 14 males, mean age\u00a0=\u00a054\u00a0\u00b1\u00a014 years) and normal LV function (Group N; <jats:italic>n<\/jats:italic>\u00a0=\u00a047, 23 males, mean age\u00a0=\u00a054\u00a0\u00b1\u00a015 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LV ejection fraction (%) was significantly lower in Group R as compared with Group N (Group R, Group N\u00a0=\u00a036\u00a0\u00b1\u00a06, 58\u00a0\u00b1\u00a04; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001); however, LV end\u2010diastolic dimension mm was not significantly different between the two study groups (Group R, Group N\u00a0=\u00a054\u00a0\u00b1\u00a05, 50\u00a0\u00b1\u00a06; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.06). Similarly, sinus QRS width (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.10), VPD\u2010burden (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.36), and body surface area (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.75) were not significantly different between Group R and Group N. The QRSd was significantly longer in Group R compared with Group N (177\u00a0\u00b1\u00a08\u00a0vs 150\u00a0\u00b1\u00a014; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Using a QRSd cut\u2010off value of 170.1\u00a0ms, VPD\u2010induced CMP was identified with a sensitivity of 73% and a specificity of 97%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RVa pacing with transmyocardial conduction time assessment was a useful method for identifying idiopathic VPD\u2010induced CMP. Using a QRSd cut\u2010off value of 170.1\u00a0ms, VPD\u2010induced CMP was identified with a sensitivity of 73% and a specificity of 97%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13553","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:26:34Z","timestamp":1542705994000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Right ventricle apex pacing identifies the presence of ventricular premature depolarizations\u2010induced cardiomyopathy"],"prefix":"10.1111","volume":"42","author":[{"given":"Sung Il","family":"Im","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kosin University Gospel Hospital Kosin University College of Medicine  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Bin","family":"Gwag","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Keun","family":"On","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-3142","authenticated-orcid":false,"given":"Kyoung\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of 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