{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:34:36Z","timestamp":1761766476808,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The posterior wall of the left atrium (LA) is a well\u2010known substrate for atrial fibrillation (AF) maintenance. Isolation of the posterior wall between the pulmonary veins (box lesion) may improve ablation success. Box lesion surface area size varies depending on the individual anatomy. This retrospective study evaluates the influence of box lesion surface area as a ratio of total LA surface area (box surface ratio) on arrhythmia recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy consecutive patients with persistent AF (63\u00a0\u00b1\u00a011\u00a0years, 53\u00a0men) undergoing computed tomography (CT) imaging and ablation procedure consisting of a first box lesion were included in this study. Box lesion surface area was measured on electroanatomical maps and total LA surface area was derived from CT. Patients were followed with 24\u2010h electrocardiography and exercise tests at 3, 6, and 12\u00a0months after AF ablation. Arrhythmia recurrence was defined as any AF\/atrial tachycardia (AT) beyond 3\u00a0months without antiarrhythmic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 13 (interquartile range =\u00a010\u201017) months, 42 (60%) patients had AF\/AT recurrence. Multivariate Cox proportional regression analysis showed that a larger box surface ratio protected against recurrence (hazard ratio [HR]\u00a0=\u00a00.81; 95% confidence interval [CI]\u00a0=\u00a00.690\u20100.955; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). Left atrial volume index (HR\u00a0=\u00a01.01 [0.990\u20101.024, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.427] and a history of mitral valve surgery (HR\u00a0=\u00a02.90; 95% CI\u00a0=\u00a00.970\u20108.693; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.057) were not associated with AF recurrence in multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A larger box lesion surface area as a ratio of total LA surface area is protective for AF\/AT recurrence after ablation for persistent AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13570","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T04:49:00Z","timestamp":1544071740000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of left atrial box surface ratio on the recurrence after ablation for persistent atrial fibrillation"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-9336","authenticated-orcid":false,"given":"Fehmi","family":"Ke\u00e7e","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J.","family":"Scholte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-6750","authenticated-orcid":false,"given":"Marta","family":"de Riva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-951X","authenticated-orcid":false,"given":"Yoshihisa","family":"Naruse","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0757-9601","authenticated-orcid":false,"given":"Masaya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Alizadeh Dehnavi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-5231","authenticated-orcid":false,"given":"Martin J.","family":"Schalij","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-1017","authenticated-orcid":false,"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-9536","authenticated-orcid":false,"given":"Serge A.","family":"Trines","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center University of Leiden  Leiden The 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