{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:43:54Z","timestamp":1789926234546,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460742"],"award-info":[{"award-number":["81460742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560063"],"award-info":[{"award-number":["81560063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcutaneous stimulation of the auricular branch of the vagus nerve (AB\u2010VNS) is a potentially noninvasive, inexpensive, and safe approach for vagus nerve stimulation that suppresses the induction and duration of atrial fibrillation and reduces sympathetic nerve outflow in healthy humans. Researchers have not determined whether AB\u2010VNS affects ventricular arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the antiarrhythmic effects of noninvasive AB\u2010VNS on ventricular arrhythmias induced by myocardial infarction (MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Twelve beagle dogs were randomly divided into the following two groups: a AB\u2010VNS group (coronary artery occlusion and noninvasive AB\u2010VNS) and a control group (coronary artery occlusion but without AB\u2010VNS). We examined spontaneous ventricular arrhythmias, ventricular electrophysiological properties, and cardiac function in conscious dogs. Morphology, fibrosis, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ultrastructure\">ultrastructure<\/jats:ext-link>s were also assessed. AB\u2010VNS significantly reduced the occurrence of spontaneous ventricular arrhythmias, including isolated premature ventricular complexes, ventricular couplets, ventricular bigeminy, ventricular trigeminy, and ventricular tachycardia. AB\u2010VNS effectively increased ventricular electrical stability, including significantly prolonged ventricular effective refractory periods, decreased the dispersion of effective refractory period, enhanced the ventricular fibrillation threshold, and decreased the maximum slope of the monophasic action potential duration restitution curve. AB\u2010VNS treatments alleviate ventricular interstitial fibrosis after MI. However, cardiac function was not improved, and MI\u2010induced ultrastructural changes in the myocardium were not reversed by 4\u00a0weeks of AB\u2010VNS. In addition, AB\u2010VNS for 4\u00a0weeks resulted in mild mitochondrial swelling within the neuronal axons of the auricular vagus fiber.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Noninvasive AB\u2010VNS reduces the occurrence of spontaneous ventricular arrhythmias in conscious dogs with MI. AB\u2010VNS increases ventricular electrical stability and alleviates ventricular interstitial fibrosis induced by MI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13585","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T11:48:37Z","timestamp":1544874517000},"page":"247-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Vagus nerve stimulation reduces ventricular arrhythmias and increases ventricular electrical stability"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-9721","authenticated-orcid":false,"given":"Buajieer\u2010guli","family":"Nasi\u2010Er","sequence":"first","affiliation":[{"name":"Xinjiang Key Laboratory of Medical Animal Model Research, Clinical Medical Research Institute First Affiliated Hospital of Xinjiang Medical University  Urumqi 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