{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:49:40Z","timestamp":1780757380011,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>A novel therapy offering cardiac resynchronization therapy (CRT) with an additional lead placed in His bundle has been reported in a few case reports and case series as improving the hemodynamical and clinical condition of patients with permanent atrial fibrillation (AF) in whom other therapeutic methods have not been successful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen consecutive patients with permanent AF, heart failure (HF), bundle branch block (BBB) with QRS complex width\u00a0&gt;130\u00a0ms, and impaired left ventricular ejection fraction (LVEF) underwent implantation of implantable cardioverter defibrillator (ICD)\/CRT systems with His bundle pacing (HBP). During the follow\u2010up, we assessed the efficacy of ICD\/CRT systems with HBP in HF treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort consisted of 14 patients with the mean age of 67.35\u00a0\u00b1\u00a010 years. The mean duration of QRS was 159.2\u00a0\u00b1\u00a028.6\u00a0ms, mean LVEF was 24.36\u00a0\u00b1\u00a010.7%, and mean follow\u2010up duration was 14.4 months. One patient died due to HF aggravation during the follow\u2010up. In the remaining 13 patients, the mean LVEF significantly improved from 24% to 38%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0015. The left ventricular end\u2010diastolic dimension decreased from 72\u00a0mm to 59\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; left ventricular end\u2010systolic dimension decreased from 59\u00a0mm to 47\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0026. The mean QRS duration shortened from 159\u00a0ms to 128\u00a0ms, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016. The mean percentage of HBP reached 97%. As a result, 92.3% of patients demonstrated significant improvement in the New York Heart Association functional class, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of atrial channel for HBP, choice of optimal ICD\/CRT pacing configuration, and optimization of pharmacological therapy resulted in a substantial narrowing of QRS width and clinical improvement in left ventricular mechanical function during the follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13611","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T19:43:45Z","timestamp":1547927025000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cardiac resynchronization therapy with His bundle 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