{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:59:22Z","timestamp":1780509562705,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The MARVEL study demonstrated at a single time point that accelerometer (ACC)\u2010based atrial sensing improves atrioventricular (AV) synchrony (AVS) in patients with AV block and a Micra pacemaker (Medtronic, Minneapolis, MN, USA). The purpose of the MARVEL Evolve substudy was to assess the performance over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective single\u2010center study compared AVS and ACC signals at two visits \u22656\u00a0months apart. Custom software was temporarily downloaded into the Micra at each visit and AVS was measured during 30\u00a0min at rest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients from the MARVEL study were enrolled. The mean (\u00b1standard deviation) age was 82.3\u00a0\u00b1\u00a06.0 years old, 67% were male, and a Micra was implanted for 6.0\u00a0\u00b1\u00a06.4 months. High\u2010degree AV block was present in four patients, whereas five with predominantly intrinsic conduction required intermittent pacing for bradycardia. The mean interval between visits was 7.1\u00a0\u00b1\u00a00.6 months. Seven patients had normal sinus node function at both visits and were included in a paired analysis. Both ACC signal amplitude (visit 2\u2010visit 1\u00a0=\u00a01.4 mG; 95% confidence interval [CI] [\u221225.8 to 28.4 mG]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.933) and AVS (visit 1: 90.8%, 95% CI [72.4, 97.4] and visit 2: 91.4%, 95% CI [63.8, 98.5]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.740) remained stable. Three patients had spontaneous atrial tachycardia. During atrial fibrillation, no atrial contraction was detected or tracked. During atrial flutter, intermittent tracking resulted in a ventricular rate of 60\u00a0\u00b1\u00a08\u00a0beats per minute (bpm); there was no ventricular pacing\u00a0&gt;100\u00a0bpm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACC signals amplitude and performance of AVS pacing were stable over time. During atrial arrhythmias, the AV synchronous pacing mode behaved safely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13615","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T04:14:46Z","timestamp":1548648886000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Behavior of leadless AV synchronous pacing during atrial arrhythmias and stability of the atrial signals over time\u2014Results of the MARVEL Evolve subanalysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-1035","authenticated-orcid":false,"given":"Christophe","family":"Garweg","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven 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Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lemme","sequence":"additional","affiliation":[{"name":"Bakken Research Center Medtronic  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leuven  Leuven Belgium"},{"name":"Department of Cardiology University Hospitals Leuven  Leuven 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