{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:35:00Z","timestamp":1771472100344,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Patients with moderate\u2010to\u2010severe chronic kidney disease (CKD) are underrepresented in clinical trials of cardiac resynchronization therapy (CRT)\u2010defibrillation (CRT\u2010D) or CRT\u2010pacing (CRT\u2010P). We sought to determine whether outcomes after CRT\u2010D are better than after CRT\u2010P over a wide spectrum of CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Clinical events were quantified in relation to preimplant estimated glomerular filtration rate (eGFR) after CRT\u2010D (n\u00a0=\u00a0410 [39.2%]) or CRT\u2010P (n\u00a0=\u00a0636 [60.8%]) implantation. Over a follow\u2010up period of 3.7 years (median, interquartile range: 2.1\u20135.7), the eGFR\u00a0&lt;\u00a060 group (n\u00a0=\u00a0598) had a higher risk of total mortality (adjusted hazard ratio [aHR]: 1.28; P\u00a0=\u00a00.017), total mortality or heart failure (HF) hospitalization (aHR: 1.32; P\u00a0=\u00a00.004), total mortality or hospitalization for major adverse cardiac events (MACEs, aHR: 1.34; P\u00a0=\u00a00.002), and cardiac mortality (aHR: 1.33; P\u00a0=\u00a00.036), compared to the eGFR \u2265 60 group (n\u00a0=\u00a0448), after covariate adjustment. In analyses of CRT\u2010D versus CRT\u2010P, CRT\u2010D was associated with a lower risk of total mortality (eGFR \u2265 60\u00a0HR: 0.65; P\u00a0=\u00a00.028; eGFR &lt; 60\u00a0HR: 0.64, P\u00a0=\u00a00.002), total mortality or HF hospitalization (eGFR \u2265 60 aHR: 0.66; P\u00a0=\u00a00.021; eGFR\u00a0&lt;\u00a060 aHR: 0.69, P\u00a0=\u00a00.007), total mortality or hospitalization for MACEs (eGFR \u2265 60 aHR: 0.70; P\u00a0=\u00a00.039; eGFR\u00a0&lt;\u00a060 aHR: 0.69, P\u00a0=\u00a00.005), and cardiac mortality (eGFR \u2265 60 aHR: 0.60; P\u00a0=\u00a00.026; eGFR\u00a0&lt;\u00a060 aHR: 0.55; P\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CRT recipients, moderate CKD is associated with a higher mortality and morbidity compared to normal renal function or mild CKD. Despite less favorable absolute outcomes, patients with moderate CKD had better outcomes after CRT\u2010D than after CRT\u2010P.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13659","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T08:46:04Z","timestamp":1552639564000},"page":"595-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Renal function and the long\u2010term clinical outcomes of cardiac resynchronization therapy with or without defibrillation"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-0223","authenticated-orcid":false,"given":"Francisco","family":"Leyva","sequence":"first","affiliation":[{"name":"Aston Medical Research Institute, Aston Medical School Aston University  Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbasin","family":"Zegard","sequence":"additional","affiliation":[{"name":"Aston Medical Research Institute, Aston Medical School Aston University  Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences University of Birmingham  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.X.","family":"Foley","sequence":"additional","affiliation":[{"name":"Great Western Hospitals NHS Foundation Trust  Swindon United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraz","family":"Umar","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences University of Birmingham  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Patel","sequence":"additional","affiliation":[{"name":"Good Hope Hospital  Sutton Coldfield Birmingham United Kingdom"},{"name":"Warwick Medical School University of Warwick  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Panting","sequence":"additional","affiliation":[{"name":"Good Hope Hospital  Sutton Coldfield Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences University of Birmingham  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shajil","family":"Chalil","sequence":"additional","affiliation":[{"name":"Blackpool Royal Infirmary  Blackpool United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Marshall","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital  Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital  Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1178"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.097"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01043.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.12.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0085-2538(15)50904-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.14.1638"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv202"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.12.009"},{"key":"e_1_2_7_11_1","unstructured":"National Institute of Health and Care Excellence.NICE technology appraisal [TA 314]: Implantable cardioverter defibrillators and cardiac resynchronisation therapy for arrhythmias and heart failure (review of TA95 and TA120).2014. Available athttps:\/\/www.nice.org.uk\/guidance\/ta314. Accessed March 12 2018."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2005.04.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002082"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.060"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-11-201306040-00007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq252"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12883"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.061"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001548"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2010.02909.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.043"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.13659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:21:15Z","timestamp":1694355675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/pace.13659"],"URL":"https:\/\/doi.org\/10.1111\/pace.13659","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]},"assertion":[{"value":"2019-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}