{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:50:59Z","timestamp":1788565859208,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supraventricular tachycardia (SVT) in children can be difficult to treat when first\u2010line therapies (beta\u2010blockade or digoxin) are not effective. Both flecainide and amiodarone are used as second\u2010line therapies. We sought to compare the efficacy and safety of flecainide and amiodarone in pediatric patients with recurrent SVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients treated with oral flecainide or oral amiodarone for SVT between 2006 and 2015 were studied. Tachycardia mechanisms included orthodromic reciprocating tachycardia (ORT), intra\u2010atrial reentrant tachycardia (IART), and ectopic atrial tachycardia (EAT). Outcomes were classified as full success, partial success (requiring additional intervention), or failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010four patients were included (median age 46 days, range 1 day to 19 years). Flecainide was used in 47 patients and amiodarone in 27 patients. Full success was achieved in 68% and 59%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.28). Partial success was achieved in 13% and 19%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.12). Treatment failed in 19% and 22%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.97). Ten crossover patients received the second medication after the first failed. Of five amiodarone\u2010to\u2010flecainide crossovers, four achieved success on flecainide alone. Of five flecainide\u2010to\u2010amiodarone crossovers, two achieved success. Minor adverse events occurred in 9% of flecainide and 22% of amiodarone patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.16). No significant differences were seen by arrhythmia subtype (36 EAT, 28 ORT, 10 IART), congenital heart disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a038), or age group (56 infants).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral flecainide and amiodarone achieved meaningful arrhythmia control in 81% and 78% of pediatric patients with recurrent SVT, respectively. Those who failed amiodarone had encouraging outcomes when changed to flecainide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13662","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T13:11:43Z","timestamp":1552655503000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A comparison of oral flecainide and amiodarone for the treatment of recurrent supraventricular tachycardia in children"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-0042","authenticated-orcid":false,"given":"Allison C.","family":"Hill","sequence":"first","affiliation":[{"name":"Division of Cardiology, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Silka","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Bar\u2010Cohen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Heart Disease in Infancy and Childhood","author":"Keith J","year":"1967"},{"key":"e_1_2_6_3_1","first-page":"380","volume-title":"Pediatric Arrhythmias: Electrophysiology and Pacing","author":"Ludomirsky 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with Wolff\u2010Parkinson\u2010White syndrome","volume":"72","author":"Shahar E","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2013.02.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun069"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90586-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90238-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw301"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-2-141"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90052-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.56.3.238"}],"container-title":["Pacing and Clinical 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