{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:59:12Z","timestamp":1771264752105,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In hypertrophic cardiomyopathy (HCM) patients implanted with an implantable cardioverter defibrillator (ICD), clinical outcomes of antitachycardia pacing (ATP) have been poorly explored. In a retrospective analysis of a cohort of consecutive HCM patients implanted with an ICD, we aimed to assess the efficacy, safety, and clinical value of ATP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort of HCM patients implanted with a transvenous ICD and followed in our center was assessed for device intervention from implantation to last clinical follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall 77 patients (45 males; mean age: 46\u00a0\u00b1\u00a016 years) were analyzed. After 67\u00a0\u00b1\u00a041 months, 24 patients had 49 ventricular tachycardia\/fibrillation (VT\/VF) appropriately treated (5.8% per year). Among 39 monomorphic VTs, ATP was effective in 27 (success rate: 69%). Mean time from VT onset to ATP delivery was 9.1\u00a0\u00b1\u00a04.9\u00a0s. The only clinical variable improving ATP success was use of beta\u2010blockers (81%\u00a0vs 50%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Out of 12 ineffectively treated VTs, one was immediately shocked, four self\u2010terminated after 18\u00a0\u00b1\u00a012\u00a0s, and seven (18%) were accelerated to a new VT. ATP was also delivered for 27 of 42 inappropriately detected episodes and induced two de novo VTs (7%). In the per patient analysis, 14 out 77 (18%) patients had one or more appropriate and effective ATP (3.4% per year), and only six (8%; 1.4% per year) received more than one ATP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ATP is moderately effective for the treatment of monomorphic VTs in HCM patients. However, the rate of appropriate ATP therapies is low, ATP is often prematurely delivered, and ATP\u2010induced arrhythmia degeneration is of concern.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13665","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T11:28:09Z","timestamp":1553340489000},"page":"610-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Safety and efficacy of anti\u2010tachycardia pacing in patients with hypertrophic cardiomyopathy implanted with an ICD"],"prefix":"10.1111","volume":"42","author":[{"given":"Carmen","family":"Adduci","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Clinical and Molecular Medicine, St. Andrea Hospital Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Semprini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, 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