{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:58:21Z","timestamp":1767905901530,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently available second\u2010generation cryoballoon (CB2) is accepted as an effective and safe tool for pulmonary vein isolation (PVI). Although much more data exist about 1\u2010year outcomes of CB2 ablation, data on long\u2010term outcomes are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to assess the long\u2010term outcomes of PVI using CB2 in a large\u2010scale symptomatic atrial fibrillation (AF) population at our tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this nonrandomized prospective observational study, a total of 486 patients with paroxysmal (71%) or persistent (29%) AF who underwent index PVI using CB2 at our hospital between January 2013 and June 2017 were enrolled. Atrial tachyarrhythmia (ATa)\u2010free survival was defined as the absence of AF, atrial flutter, or atrial tachycardia recurrence \u226530 s following a 3 months blanking period. Predictors of recurrence were evaluated by univariate and multivariate Cox proportional hazards regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute procedural success rate was 99.8% (1898\/1902 PVs). Mean procedural and fluoroscopy time were 64.9 \u00b1 9.2 and 12.1 \u00b1 2.6, respectively. At median 39 (interquartile range: 26\u201056) months follow\u2010up, ATa\u2010free survival was 78.6% after a single procedure (280\/345 [81.2%] for paroxysmal AF vs. 102\/141 [72.3%] for persistent AF, <jats:italic>P<\/jats:italic> = .019) and 84.4% after a mean 1.48 \u00b1 0.42 ablations. Cox regression analysis showed that left atrium diameter, duration of AF history, and early ATa recurrence were found as the independent predictors of late recurrence. Phrenic nerve palsy was observed in 17 (3.5%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CB2\u2010based PVI is effective to maintain sinus rhythm in a significant proportion of paroxysmal and persistent AF patients with an acceptable complication rate at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13721","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T08:16:09Z","timestamp":1558340169000},"page":"910-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term outcomes of pulmonary vein isolation using second\u2010generation cryoballoon during atrial fibrillation ablation"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-1706","authenticated-orcid":false,"given":"Ugur","family":"Canpolat","sequence":"first","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Kocyigit","sequence":"additional","affiliation":[{"name":"Cardiology Clinics Afyonkarahisar Dinar State Hospital  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Ulvi","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Coteli","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf Ziya","family":"Sener","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology, Faculty 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikmet","family":"Yorgun","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology, Faculty of Medicine Hacettepe University  Ankara Turkey"},{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kudret","family":"Aytemir","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology, Faculty of Medicine Hacettepe University  Ankara 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