{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:52:02Z","timestamp":1762005122008,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T00:00:00Z","timestamp":1562457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The perioperative management of anticoagulation with the use of subcutaneous implantable cardioverter\u2010defibrillator (S\u2010ICD) implantation is still evolving.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to assess whether it is safe to perform S\u2010ICD implantation with uninterrupted warfarin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multi\u2010center retrospective review of patients undergoing S\u2010ICD implantation between October 1, 2012 and June 30, 2017. Forty\u2010eight patients underwent successful S\u2010ICD implantation during the study period. The most common indication for implantation was primary prevention of sudden cardiac death. In 23 (47.9%) patients, warfarin was continued without any interruption. In 25 (52.1%) patients, warfarin was interrupted prior to implantation. The incidence of clinically significant lateral pocket hematoma was compared in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean international normalized ratio was 2.0\u00a0\u00b1\u00a00.4 in the uninterrupted group and 1.4\u00a0\u00b1\u00a00.4 for the interrupted group. A total of seven patients developed a hematoma at the lateral pocket. No patient developed a hematoma at the parasternal pockets. Six patients in the uninterrupted group (26.1%) and one patient in the interrupted group (0.04%) developed a significant lateral pocket hematoma (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). The concomitant use of dual antiplatelet therapy did not increase the risk of hematoma. There was no significant difference between HASBLED and CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>VASc scores between the groups. None of the patients with a hematoma developed infection or required hematoma evacuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The uninterrupted use of warfarin in the perioperative period of S\u2010ICD implantation is associated with an increased risk of lateral pocket hematoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13754","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T07:40:47Z","timestamp":1561362047000},"page":"1111-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Increased risk of hematoma with uninterrupted warfarin in patients undergoing implantation of subcutaneous implantable cardioverter defibrillator"],"prefix":"10.1111","volume":"42","author":[{"given":"Christopher","family":"Evenson","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Electrophysiology Section, Ross Heart Hospital The Wexner Medical Center at the Ohio State University Medical Center  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil","family":"Saour","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Electrophysiology Section, Ross Heart Hospital The Wexner Medical Center at the Ohio State University Medical Center  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-7618","authenticated-orcid":false,"given":"Muhammad R.","family":"Afzal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Electrophysiology Section, Ross Heart Hospital The Wexner Medical Center at the Ohio State University Medical Center  Columbus 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Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-4028","authenticated-orcid":false,"given":"Raul","family":"Weiss","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Electrophysiology Section, Ross Heart Hospital The Wexner Medical Center at the Ohio State University Medical Center  Columbus 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