{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:05Z","timestamp":1747187465228,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) improves the morbidity and mortality rate in patients with left bundle\u2010branch block (LBBB); however, some LBBB patients are non\u2010responders for CRT. Previous studies have shown that a transmural functional line block alters the left ventricular (LV) activation sequence, and that the presence of a line block is predictive for responders. We investigated whether responders could be predicted in patients with LBBB by 2\u2010dimensional (2\u2010D) speckle tracking strain imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 54 patients with LBBB, who underwent echocardiography before and 6 months after CRT implantation. A responder was defined by a decrease in the LV end\u2010systolic volume\u00a0&gt;15% at the 6\u2010month follow\u2010up. We calculated a difference in the time from QRS onset to maximum strain between adjacent segments and defined the Tmax\u2010diff as the maximum difference among six intersegments. We compared the Tmax\u2010diff between responders and non\u2010responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 54 patients, 37 patients were identified as responders. The Tmax\u2010diff of the responders was significantly longer than that of the non\u2010responders (309.6 \u00b1 168.6\u00a0ms vs 181.5 \u00b1 138.4\u00a0ms, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009). Furthermore, Tmax\u2010diff \u2265 195\u00a0ms was higher in the septal and the anterior area. And patients with a Tmax\u2010diff \u2265 195\u00a0ms tended to be responders (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study showed that discontinuous contraction of the LV could be detected in CRT responders by 2\u2010D speckle tracking strain imaging, which may be a useful tool to identify the contraction pattern of patients with LBBB and predict CRT responders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13759","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T08:41:07Z","timestamp":1563525667000},"page":"1204-1212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discontinuous contraction in the left ventricle assessed by 2\u2010D speckle tracking echocardiography benefits from CRT"],"prefix":"10.1111","volume":"42","author":[{"given":"Aya","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-5672","authenticated-orcid":false,"given":"Yasuya","family":"Inden","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-5498","authenticated-orcid":false,"given":"Satoshi","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiovascular Therapeutics  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Mamiya","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of 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