{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:06Z","timestamp":1747187466990,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T00:00:00Z","timestamp":1566086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no consensus in the literature regarding what is the responsible mechanism of left ventricular dyssynchrony; septal dyskinesia or late movement of left ventricle (LV) lateral wall. We aim to evaluate the abnormal systolic motion in each myocardial segment and the improvement of LV systolic function with pulsed tissue Doppler imaging (TDI) in patients undergoing cardiac resynchronization therapy (CRT) with left bundle branch block (LBBB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 26 patients undergoing CRT implantation with LBBB, wide QRS duration (\u2265120\u00a0ms), and low ejection fraction (EF) (&lt;35%) were included. Pulsed TDI was taken from apical 4\u2010chamber view and parasternal short axis view (PSAX). All echocardiographic parameters were measured when CRT is on and off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Systolic ejection time (ET) of anteroseptal and posterolateral wall of LV in PSAX was statistically significantly longer in CRT on group (321.6\u00a0\u00b1\u00a062.7\u00a0vs 237.5\u00a0\u00b1\u00a059.3 ms, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; 323.9\u00a0\u00b1\u00a058.0\u00a0vs 289.4\u00a0\u00b1\u00a043.7 ms, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015, respectively). In apical 4\u2010chamber view, septal annulus systolic ET is significantly longer in CRT on group than CRT off group (315.8\u00a0\u00b1\u00a057.2\u00a0vs 287.3 \u00b1 42.2, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014). Also, there was a strong correlation between systolic ET of the septum in PSAX with aortic velocity time integral (VTI), QRS duration and EF (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.587, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.479, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.440, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.025; respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circumferential contraction of septal myocardial fibers is improved with CRT and it is strongly correlated with increase of aortic VTI and shortening of QRS duration. These findings predict the deterioration of septal contraction as the main mechanism in patients with LBBB pattern and, CRT may improves myocardial contraction by correcting septal systolic motion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13772","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:23:48Z","timestamp":1565191428000},"page":"1213-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improvement of abnormal systolic motion of the interventricular septum with cardiac resynchronization therapy"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-6801","authenticated-orcid":false,"given":"Belma","family":"Yaman","sequence":"first","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice S","family":"Kemal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurdaer","family":"D\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Adana City Training and Research Hospital  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Cerit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-5431","authenticated-orcid":false,"given":"Song\u00fcl","family":"Usalp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit","family":"Y\u00fcksek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"G\u00fcnsel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Duygu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Akp\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441202"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2008.07.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.09.078"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer243"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.7.1486"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.6.1304"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn481"},{"key":"e_1_2_7_14_1","first-page":"38","volume-title":"The EACVI Textbook of Echocardiography","author":"Cameli M","year":"2017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.32.2.301"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.3.248"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.24.3.339"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00719.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2007.00523.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131184.40893.40"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.508457"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp107"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","unstructured":"PrinzenFW.Imaging or imagination of cardiac mechanics?2009Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Jeju Island Korea: IEEE Engineering in Medicine and Biology Society.","DOI":"10.1109\/IEMBS.2009.5333353"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.5.914"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer243"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.845"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1991.tb04040.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-014-0233-1"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.12.013"},{"key":"e_1_2_7_31_1","first-page":"103","article-title":"The electrocardiographic characteristics of septal flash in patients with left bundle branch block","volume":"19","author":"Corteville B","year":"2017","journal-title":"Europace"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12203"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.07.006"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.13772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T16:20:09Z","timestamp":1694276409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,18]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/pace.13772"],"URL":"https:\/\/doi.org\/10.1111\/pace.13772","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2019,8,18]]},"assertion":[{"value":"2019-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}