{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:04:54Z","timestamp":1762999494194,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Subcutaneous implantable cardioverter\u2010defibrillator (S\u2010ICD) is gaining in popularity for primary and secondary prevention of sudden cardiac death. The objective was to evaluate the safety and clinical effectiveness of the S\u2010ICD for prevention of sudden cardiac death compared to transvenous cardioverter\u2010defibrillator (TV\u2010ICD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review with meta\u2010analyses was performed. The electronic databases MEDLINE, EMBASE, SCI, and Cochrane Central Register of Controlled Trials were consulted in March 2018 with no restrictions on publication date. Predefined criteria were used to determine inclusion of studies and to assess their methodologic quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten longitudinal\u2010observational studies with comparison group presenting moderate methodologic flaws were included (<jats:italic>N<\/jats:italic>\u00a0=\u00a07820). The combination of results indicates that health\u2010related quality of life is not significantly different between S\u2010ICD and TV\u2010ICD groups (Physical health: MD\u00a0=\u00a02.90; 95% CI\u00a0=\u00a0\u22123.88, 9.68\/Mental health: MD\u00a0=\u00a00.13; 95% CI\u00a0=\u00a0\u22122.11, 2.37). Mortality occurred in 4.4% of S\u2010ICD patients and 5.9% of TV\u2010ICD patients died (OR\u00a0=\u00a00.79; 95% CI\u00a0=\u00a00.50, 1.24). The incidence of infections (OR\u00a0=\u00a01.79; 95% CI\u00a0=\u00a00.93, 3.43) and inappropriate shocks (OR\u00a0=\u00a01.28, 95% CI\u00a0=\u00a00.91, 1.78) is not significantly different between both groups. The S\u2010ICD reduces complications related to electrodes\/leads (OR\u00a0=\u00a00.13, 95% CI\u00a0=\u00a00.05, 0.29) and has lower electrodes\/leads movement compared with TV\u2010ICD (OR\u00a0=\u00a00.26; 95% CI 0.10, 0.67). In contrast, pneumothorax is more likely in TV\u2010ICD than S\u2010ICD (OR\u00a0=\u00a00.17; 95% CI\u00a0=\u00a00.03, 0.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>S\u2010ICD reduces electrodes\/leads movement, electrodes\/leads related complications, and pneumothorax. Our study did not demonstrate a statistically significant difference in mortality, health\u2010related quality of life, and infection rate between S\u2010ICD and TV\u2010ICD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13774","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:24:55Z","timestamp":1565339095000},"page":"1253-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Subcutaneous implantable cardioverter\u2010defibrillator in primary and secondary prevention of sudden cardiac death: A meta\u2010analysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-1756","authenticated-orcid":false,"given":"Beatriz","family":"Le\u00f3n Salas","sequence":"first","affiliation":[{"name":"Canary Islands Foundation of Health Research (FUNCANIS)  Santa Cruz de Tenerife Spain"},{"name":"Spanish Network of Health Technology Assessment (RedETS)  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda M.","family":"Trujillo\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Canary Islands Foundation of Health Research (FUNCANIS)  Santa Cruz de Tenerife Spain"},{"name":"Spanish Network of Health Technology Assessment (RedETS)  Spain"},{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Center for Biomedical Research of the Canary Islands (CIBICAN)  Santa Cruz de Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garc\u00eda Garc\u00eda","sequence":"additional","affiliation":[{"name":"Quality and Patient Safety Unit Nuestra Se\u00f1ora de Candelaria University Hospital  Santa Cruz de Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Ramallo Fari\u00f1a","sequence":"additional","affiliation":[{"name":"Canary Islands Foundation of Health Research (FUNCANIS)  Santa Cruz de Tenerife Spain"},{"name":"Spanish Network of Health Technology Assessment (RedETS)  Spain"},{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Center for Biomedical Research of the Canary Islands (CIBICAN)  Santa Cruz de Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Garc\u00eda Quintana","sequence":"additional","affiliation":[{"name":"Cardiology Unit Dr. Negrin University Hospital of Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Quir\u00f3s L\u00f3pez","sequence":"additional","affiliation":[{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Internal Medicine Service Costa del Sol Hospital  Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Serrano\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Spanish Network of Health Technology Assessment (RedETS)  Spain"},{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Center for Biomedical Research of the Canary Islands (CIBICAN)  Santa Cruz de Tenerife Spain"},{"name":"Evaluation Service of the Canary Islands Health Service (SESCS) Canary Islands Health Service  Santa Cruz de Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2012.03.032"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(99)75027-X"},{"key":"e_1_2_9_4_1","unstructured":"Northwest Heart Center (NWHC).Heart Diseases. 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