{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:22:53Z","timestamp":1770038573298,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Loss of biventricular stimulation can result in nonresponse to cardiac resynchronization therapy (CRT). Problems associated with the left ventricular (LV) lead and LV sensing can be challenging to detect and their incidence is unclear. The purpose of this study was to investigate mechanisms of loss of biventricular pacing due to LV lead\u2010 and LV sensing\u2010associated problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this bicentric study, CRT patients were surveilled using a novel remote monitoring algorithm from Biotronik (Germany) that registers LV electrograms (EGMs) during intermittent loss of resynchronization. The episodes were analyzed to assess the mechanisms of resynchronization interruptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 582 EGMs from 61 patients. During a median follow\u2010up of 6 months, 59% of the patients had such episodes. The majority of the episodes (61%) were related to inappropriate inhibition of LV pacing, mostly due to upper rate lock\u2010in caused by LV sensing (58%). In contrast, 8% of episodes showed intermittent loss of LV capture, which was identified thanks to LV sensing. The remaining 31% of episodes were due to physiological reasons for resynchronization interruptions (eg, supraventricular tachycardia [18%], premature beats [8%], and others [5%]). Patients with CRT interruption episodes had lower resynchronization rates (median: 98.5%\u00a0vs 100%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inadequate programming (active LV sensing with T\u2010wave protection) is the main cause of impaired resynchronization in devices with LV sensing. In general, we recommend the deactivation of the LV T\u2010wave protection function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13883","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T12:24:47Z","timestamp":1581337487000},"page":"332-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Causes of impaired biventricular pacing in cardiac resynchronization devices with left ventricular sensing"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-0110","authenticated-orcid":false,"given":"Andreas","family":"Haeberlin","sequence":"first","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"},{"name":"Department of Cardiology, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"},{"name":"Sitem Center for Translational Medicine and Biomedical Entrepreneurship University of Bern  Bern Switzerland"},{"name":"Act-Inno, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Ploux","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Noel","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9mi","family":"Chauvel","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Welte","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Marchand","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Ha\u00efssaguerre","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ritter","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Cardio\u2010Thoracic Unit  Pessac France"},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Bordeaux University  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Eschalier","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU Clermont\u2010Ferrand, Clermont\u2010Ferrand, France and Universit\u00e9 Clermont Auvergne, CHU Clermont\u2010Ferrand, CNRS, SIGMA Clermont Institut Pascal  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bordachar","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), 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