{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:32:59Z","timestamp":1770748379786,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ability to differentiate right ventricular outflow tract (RVOT) from coronary cusp (CC) site of origin (SOO) by 12\u2010lead ECG in pediatric patients may impact efficacy and procedural time. The objective of this study was to predict RVOT versus CC SOO by ECG in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients (&lt;21 years) without structural heart disease with RVOT or CC premature ventricular contraction (PVC) ablations performed (2014\u20102018) were evaluated through multi\u2010institution retrospective review. Demographics, ECG PVC parameters, ablation site, recurrence, and repeat procedures were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients were evaluated (mean age 14.6 years, weight 60.6\u00a0kg): 11 CC and 26 RVOT PVC SOO. CC PVCs were less likely to exhibit left bundle branch block (64%\u00a0vs 100%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), had larger R\u2010wave amplitude in V1 (0.27\u00a0vs 0.11\u00a0mV, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), larger R\/S ratio in V1 (0.37\u00a0vs 0.09, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), and had precordial transition in V3 or earlier (73%\u00a0vs 15%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). A composite score was created with the following variables: isodiphasic or positive QRS in V1, R\/S ratio in V1\u00a0&gt;\u00a00.05, S wave in V1\u00a0&lt;\u00a00.9\u00a0mV, and precordial transition at or before V3. Composite score \u2265 2 was associated with a CC SOO (OR 42.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, and AUC 0.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>12\u2010lead ECG of PVCs from the CC was associated with larger V1 R\u2010wave amplitude, larger R\/S ratio in V1, and precordial transition at or before V3. A composite score may help predict PVC\/VT arising from the CC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13885","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T15:48:49Z","timestamp":1581349729000},"page":"308-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can the 12\u2010lead ECG distinguish RVOT from aortic cusp PVCs in pediatric patients?"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-8471","authenticated-orcid":false,"given":"Bradley C.","family":"Clark","sequence":"first","affiliation":[{"name":"Division of Cardiology Children's Hospital at Montefiore  Bronx New York"},{"name":"Department of Pediatrics Albert Einstein College of Medicine  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Ceresnak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford School of Medicine  Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Pass","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Kravis Children's Hospital  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Nappo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's Hospital at Montefiore  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Sumihara","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's National Health System  Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Dubin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford School of Medicine  Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Motonaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford School of Medicine  Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P.","family":"Moak","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's National Health System  Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.44.3.304"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.51.2.179"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02079464"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084590"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.273"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.10.047"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.59.654"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun121"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13126"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12105"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.05.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.02.031"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00287-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.11.023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01767-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12392"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0561-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup231"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.13885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.13885","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.13885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T02:51:01Z","timestamp":1694055061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.13885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/pace.13885"],"URL":"https:\/\/doi.org\/10.1111\/pace.13885","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"2019-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}