{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:04:37Z","timestamp":1778162677089,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T00:00:00Z","timestamp":1588377600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional treatment strategies for catecholaminergic polymorphic ventricular tachycardia (CPVT) include avoidance of strenuous exercise and competitive sports, drugs such as \u00df\u2010blockers and flecainide and, cervical sympathectomy. An implantable cardioverter\u2010defibrillator (ICD) has been utilized if the response to these strategies is inadequate; however, ICD use in CPVT patients, in addition to usual complications, is associated with an increased risk of life\u2010threatening electrical storm. Ivabradine is a selective inhibitor of hyperpolarization\u2010activated cyclic nucleotide\u2010gated potassium channel 4 generated funny current (<jats:italic>I<\/jats:italic><jats:sub>f<\/jats:sub>), which has been shown to be efficacious in suppression of inappropriate sinus tachycardia, junctional tachycardia, atrial tachycardia, and ventricular ectopy in humans. We report an 18\u2010year\u2010old male with a severe CPVT phenotype refractory to flecainide, nadolol, and sympathectomy who exhibited suppression of ventricular arrhythmias after initiation of ivabradine. These findings are of importance as ivabradine could be an important add\u2010on therapy in CPVT patients who are drug refractory or are unable to continue conventional therapies at the recommended doses.<\/jats:p>","DOI":"10.1111\/pace.13913","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T17:28:39Z","timestamp":1586280519000},"page":"527-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ventricular arrhythmia suppression with ivabradine in a patient with catecholaminergic polymorphic ventricular tachycardia refractory to nadolol, flecainide, and sympathectomy"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-840X","authenticated-orcid":false,"given":"Utkarsh","family":"Kohli","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Comer Children's Hospital and the Pritzker School of Medicine of the University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid","family":"Aziz","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Care, Heart and Vascular Center Pritzker School of Medicine of the University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Beaser","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Care, Heart and Vascular Center Pritzker School of Medicine of the University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemal M.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Care, Heart and Vascular Center Pritzker School of Medicine of the University of Chicago  Chicago 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