{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:01:40Z","timestamp":1791403300317,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated the risk of subclinical atrial fibrillation (AF) in patients with central retinal artery occlusion (CRAO) compared to those with cryptogenic stroke using implantable loop recorders (ILR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of 273 consecutive patients who had ILRs inserted at our institution for either cryptogenic stroke (n\u00a0=\u00a0227) or CRAO (n\u00a0=\u00a046). Our primary endpoint was a time to event analysis for the new diagnosis of AF by ILR. Univariable and multivariable Cox proportional hazard models were used to determine the predictors of time\u2010to\u2010AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 patients were found to have newly diagnosed AF by remote monitoring of the ILR. AF was detected in 57 of 227 (25%) cryptogenic stroke patients by the end of a maximum 5.1 years follow\u2010up and in seven of 46 (15%) CRAO patients by the end of a maximum 3.6 years follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.215, log\u2010rank test). The Kaplan\u2010Meier estimates for freedom from AF was 59.4% for CRAO and 66.6% for cryptogenic stroke (<jats:italic>P<\/jats:italic>\u00a0=\u00a0NS, log\u2010rank test). Baseline variables predicting AF included older patients, higher CHADS<jats:sub>2<\/jats:sub>VASC score, longer PR interval on initial EKG evaluation, and mitral annular calcification on transthoracic echocardiogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with CRAO are at risk for subclinical AF, similar to those with cryptogenic stroke. Long\u2010term monitoring to detect AF may lead to changes in pharmacotherapy to reduce the risk for subsequent stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13990","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T05:10:11Z","timestamp":1592802611000},"page":"992-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Atrial fibrillation post central retinal artery occlusion: Role of implantable loop recorders"],"prefix":"10.1111","volume":"43","author":[{"given":"Ryan A.","family":"Watson","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wellings","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rittu","family":"Hingorani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhan","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-6405","authenticated-orcid":false,"given":"Daniel R.","family":"Frisch","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-5025","authenticated-orcid":false,"given":"Reginald T.","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-7812","authenticated-orcid":false,"given":"Behzad B.","family":"Pavri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-124X","authenticated-orcid":false,"given":"Robert C.","family":"Sergott","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, The WIlliam Annesley Eye Brain Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-6118","authenticated-orcid":false,"given":"Arnold J.","family":"Greenspon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Thomas Jefferson University Hospital  Philadelphia 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