{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:23Z","timestamp":1747187363258,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the 123\u2010study, we prospectively assessed, in a randomized fashion, the minimal cryoballoon application time necessary to achieve pulmonary vein (PV) isolation (PVI) in patients with paroxysmal atrial fibrillation (AF) with the aim to reduce complications by shortening the application duration. The first results of this study demonstrated that shortened cryoballoon applications\u00a0(&lt;2 minutes) resulted in less phrenic nerve injury (PNI) without compromising acute isolation efficacy for the right PVs. We now report the 1\u2010year follow\u2010up results regarding safety and efficacy of shorter cryoballoon applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 222 patients with AF were randomized to two applications of 1\u00a0min \u201cshort,\u201d 2\u00a0min \u201cmedium,\u201d or 3\u00a0min \u201clong\u201d duration, 74 per group. Recurrence of AF and PV reconduction at 1\u2010year follow\u2010up were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall 1\u2010year freedom from AF was 79% and did not differ significantly between the short, medium, and long application groups (77%, 74%, and 85% for short, medium, and long application groups, respectively; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.07). In 30 patients, a redo PVI procedure was performed. For all four PVs, there was no significant difference in reconduction between the three groups. Reconduction was most common in the left superior PV (57%). The right superior PV (RSPV) showed significantly less reconduction (17%) compared to the other PVs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Shortening cryoballoon applications of the RSPV to\u00a0&lt;2 minutes results in less PNI, while acute success and 1\u2010year freedom from AF are not compromised. Therefore, shorter cryoballoon applications (especially) in the RSPV could be used to reduce PNI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14062","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T08:33:22Z","timestamp":1600331602000},"page":"1173-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shorter RSPV cryoapplications result in less phrenic nerve injury and similar 1\u2010year freedom from atrial fibrillation"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-8905","authenticated-orcid":false,"given":"Marleen M.D.","family":"Molenaar","sequence":"first","affiliation":[{"name":"Medisch Spectrum Twente  Enschede The Netherlands"},{"name":"Universiteit Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hesselink","sequence":"additional","affiliation":[{"name":"Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-0132","authenticated-orcid":false,"given":"Rachel M.A.","family":"ter Bekke","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcoen F.","family":"Scholten","sequence":"additional","affiliation":[{"name":"Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy","family":"Manusama","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Pison","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk 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