{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:24Z","timestamp":1747187364190,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biventricular (BiV) pacing increases transmural repolarization heterogeneity due to epicardial to endocardial conduction from the left ventricular (LV) lead. However, limited evidence is available on concomitant changes in ventricular depolarization and repolarization and long\u2010term outcomes of BiV pacing. Therefore, we investigated associations of BiV pacing\u2010induced concomitant changes in ventricular depolarization and repolarization with mortality (i.e., LV assist device, heart transplantation, or all\u2010cause mortality) and sustained ventricular arrhythmia endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive BiV\u2010defibrillator recipients with digital preimplantation and postimplantation electrocardiograms recorded between 2006 and 2015 at Duke University Medical Center were included. We calculated changes in QRS duration and corrected JT (JTc) interval and split them by median values. For simplicity, these variables were named QRS<jats:sub>decreased<\/jats:sub> (\u2264 \u221212\u00a0ms), QRS<jats:sub>increased<\/jats:sub> (&gt;\u00a0\u201312\u00a0ms), JTc<jats:sub>decreased<\/jats:sub> (\u226422\u00a0ms), and JTc<jats:sub>increased<\/jats:sub> (&gt;\u00a022\u00a0ms) and subsequently used to construct four mutually exclusive groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 528 patients (median age, 68 years; male, 69%). No correlation between changes in QRS duration and JTc interval was observed (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.295). Compared to QRS<jats:sub>decreased<\/jats:sub>\/JTc<jats:sub>increased<\/jats:sub>, increased risk of the composite mortality endpoint was associated with QRS<jats:sub>decreased<\/jats:sub>\/JTc<jats:sub>decreased<\/jats:sub> (hazard ratio [HR]\u00a0=\u00a01.62; 95% confidence interval [CI]\u00a0=\u00a01.09\u20102.43), QRS<jats:sub>increased<\/jats:sub>\/JTc<jats:sub>decreased<\/jats:sub> (HR\u00a0=\u00a01.86; 95% CI\u00a0=\u00a01.27\u20102.71), and QRS<jats:sub>increased<\/jats:sub>\/JTc<jats:sub>increased<\/jats:sub> (HR\u00a0=\u00a02.25; 95% CI\u00a0=\u00a01.52\u20103.35). No QRS\/JTc group was associated with excess sustained ventricular arrhythmia risk (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.400).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among BiV\u2010defibrillator recipients, QRS<jats:sub>decreased<\/jats:sub>\/JTc<jats:sub>increased<\/jats:sub> was associated with the most favorable long\u2010term survival free of LV assist device, heart transplantation, and sustained ventricular arrhythmias. Our findings suggest that improved electrical resynchronization may be achieved by assessing concomitant changes in ventricular depolarization and repolarization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14065","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T07:45:12Z","timestamp":1600069512000},"page":"1333-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concomitant changes in ventricular depolarization and repolarization and long\u2010term outcomes of biventricular pacing"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-7484","authenticated-orcid":false,"given":"Christoffer","family":"Polcwiartek","sequence":"first","affiliation":[{"name":"Division of Cardiology Duke University Medical Center  Durham North Carolina"},{"name":"Department of Cardiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology Yale School of Medicine  New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper","family":"Emerek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kisslo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zak","family":"Loring","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke University Medical Center  Durham North Carolina"},{"name":"Duke Clinical Research Institute  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Kragholm","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital  Aalborg 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