{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:55Z","timestamp":1787015815821,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Combined catheter ablation (CA) and left atrial appendage closure (LAAC) have proven to be a feasible and safe strategy in treating patients with nonvalvular atrial fibrillation (AF). However, the interactions between CA and LAAC have not been systematically explored. We analyzed the impact of CA on long\u2010term outcomes of LAAC in patients with AF treated with the hybrid procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 107 consecutive patients with AF who underwent LAAC were divided into two groups: group A (n\u00a0=\u00a061) included patients who underwent CA followed by LAAC during the same procedure and group B (n\u00a0=\u00a046) included patients who underwent LAAC only. All patients underwent systematic transesophageal echocardiography (TEE) follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In group A, CA resulted in severe edema of the left atrial ridge (LAR), which manifested as an increase in LAR thickness from 4.6 \u00b1 0.4\u00a0mm before CA to 6.8 \u00b1 0.6\u00a0mm (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) after CA. TEE at 45 days showed that the incidence of peri\u2010device leakage was significantly higher in group A than in group B (45.9%\u00a0vs 4.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). At the 12\u2010month follow\u2010up, the peri\u2010device leakage rate remained higher in group A than in group B (14.8%\u00a0vs 2.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Three (4.9%) patients in group A experienced transient ischemia attacks; no events were reported in group B during the 1\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Edema of LAR with the single\u2010stage procedure that consists of CA followed by LAAC could result in increased peri\u2010device leakage and decreased compression rate over time, which may be also associated with elevated risk profiles when compared with an LAAC\u2010only procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.14084","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T01:27:27Z","timestamp":1601515647000},"page":"1358-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["One\u2010stop hybrid procedure combining catheter ablation and left atrial appendage closure increases long\u2010term risk for adverse events in patients with atrial fibrillation"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-7010","authenticated-orcid":false,"given":"Xue\u2010Xun","family":"Li","sequence":"first","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"},{"name":"Department of Cardiology Yu\u2010Huang\u2010Ding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tian","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-1114","authenticated-orcid":false,"given":"Li\u2010Jun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Nan","family":"He","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yu\u2010Huang\u2010Ding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing 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outcomes after left atrial appendage closure compared with long\u2010term warfarin: a pooled, patient\u2010level analysis of the WATCHMAN randomized trial experience","volume":"8","author":"Price MJ","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61343-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw295"},{"issue":"3","key":"e_1_2_7_15_1","first-page":"2094","article-title":"Combination of catheter ablation for non\u2010valvular atrial fibrillation and left atrial appendage occlusion in a single procedure","volume":"16","author":"Li X","year":"2018","journal-title":"Exp Ther 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