{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:54:13Z","timestamp":1762005253806,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 73\u2010year\u2010old gentleman with dilated cardiomyopathy, left bundle branch block and a left ventricular (LV) ejection fraction of 20% was implanted with two LV leads in a tri\u2010ventricular cardiac resynchronisation therapy defibrillator (CRT\u2010D) trial. As a part of the trial he was programmed with fusion\u2010based CRT therapy with dual LV lead only pacing. The patient presented to local heart failure service 12 years after implant, after a positive response to CRT therapy, with increase in fatigue, shortness of breath and bilateral pitting oedema. The patient sent a remote monitoring transmission that suggested loss of capture on one of the LV leads. This coupled with atrial ectopics was producing a high burden of pacemaker\u2010mediated tachycardia (PMT) that was not seen when both LV leads had been capturing. What is the mechanism for this? Dual LV\u2010lead tri\u2010ventricular leads have been shown to have variable improvements in CRT response but with an increased complexity of implant procedure. This is the first case report of PMT\u2010induced heart failure exacerbation in a tri\u2010ventricular device following loss of LV capture of one lead.<\/jats:p>","DOI":"10.1111\/pace.14089","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T02:27:07Z","timestamp":1602728827000},"page":"151-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pacemaker\u2010mediated tachycardia in a dual\u2010lead CRT\u2010D: What is the mechanism?"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-5453","authenticated-orcid":false,"given":"Christopher","family":"Monkhouse","sequence":"first","affiliation":[{"name":"Barts Heart Centre West Smithfield  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Cambridge","sequence":"additional","affiliation":[{"name":"Barts Heart Centre West Smithfield  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony W.C.","family":"Chow","sequence":"additional","affiliation":[{"name":"Abbott Ltd  Solihull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-227X","authenticated-orcid":false,"given":"Jonathan","family":"Behar","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02375.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90308-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960140911"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12098"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv140"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.07.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03676.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2018.1443002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.896305"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.07.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.992552"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-014-9971-2"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.14089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T08:43:54Z","timestamp":1693644234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/pace.14089"],"URL":"https:\/\/doi.org\/10.1111\/pace.14089","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2020,11,8]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}