{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:25:05Z","timestamp":1792686305746,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It was reported that intravenous amiodarone might induce ventricular fibrillation for acute treatment in patients with atrial fibrillation (AF) and Wolff\u2010Parkinson\u2010White (WPW) syndrome. No study was done to assess its application comprehensively in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective analysis and undertaken by reviewing medical records and electronic databases to search for patients admitted with tachycardia resulting from WPW syndrome and AF, who have intravenously administrated amiodarone at the emergency department from January 2008 to June 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients were involved in this study, of which 27 were males. The mean age of the patients was 47.8 \u00b1 17.0 years. The mean systolic blood pressure and diastolic blood pressure were 111.9 \u00b1 18.3\u00a0mmHg and 76.1 \u00b1 14.6\u00a0mmHg, respectively. The mean heart rate was 171 (150\u2010189) beats per minute. Half of the patients (53.3%) had no comorbidities, and only one had prior syncope. Nearly 17 patients (56.7%) started with a loading dose of 150\u00a0mg. No ventricular acceleration or VF developed. The incidence of hypotension was 3.3% (1\/30). Eighteen patients (60.0%) restored to sinus rhythm by amiodarone with the conversion time of 486.0 (229.0\u20101278.0) minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous amiodarone might be an alternative for acute treatment of AF and WPW syndrome in patients characterized by stable hemodynamics, relatively low admission heart rate, few comorbidities, elder age, and no prior syncope. The loading dosage of 150\u00a0mg appeared to be preferred, and the maintenance period was better to less than 12\u00a0hours. Monitoring and electrolyte correction were also necessary. It is essential to keep a defibrillator nearby during pharmacologic cardioversion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14113","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:24:41Z","timestamp":1603970681000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The use of intravenous amiodarone in patients with atrial fibrillation and Wolff\u2010Parkinson\u2010White syndrome"],"prefix":"10.1111","volume":"44","author":[{"given":"Jiameng","family":"Ren","sequence":"first","affiliation":[{"name":"Emergency and Intensive Care Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of 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