{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:37:33Z","timestamp":1787236653259,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We recently developed two noninvasive methodologies to help guide VT ablation: population\u2010derived automated VT exit localization (PAVEL) and virtual\u2010heart arrhythmia ablation targeting (VAAT). We hypothesized that while very different in their nature, limitations, and type of ablation targets (substrate\u2010based vs. clinical VT), the image\u2010based VAAT and the ECG\u2010based PAVEL technologies would be spatially concordant in their predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective is to test this hypothesis in ischemic cardiomyopathy patients in a retrospective feasibility study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four post\u2010infarct patients who underwent LV VT ablation and had pre\u2010procedural LGE\u2010CMRs were enrolled. Virtual hearts with patient\u2010specific scar and border zone identified potential VTs and ablation targets. Patient\u2010specific PAVEL based on a population\u2010derived statistical method localized VT exit sites onto a patient\u2010specific 238\u2010triangle LV endocardial surface.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten induced VTs were analyzed and 9\u2010exit sites were localized by PAVEL onto the patient\u2010specific LV endocardial surface. All nine predicted VT exit sites were in the scar border zone defined by voltage mapping and spatially correlated with successful clinical lesions. There were 2.3 \u00b1 1.9 VTs per patient in the models. All five VAAT lesions fell within regions ablated clinically. VAAT targets correlated well with 6 PAVEL\u2010predicted VT exit sites. The distance between the center of the predicted VT\u2010exit\u2010site triangle and nearest corresponding VAAT ablation lesion was 10.7 \u00b1 7.3\u00a0mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VAAT targets are concordant with the patient\u2010specific PAVEL\u2010predicted VT exit sites. These findings support investigation into combining these two complementary technologies as a noninvasive, clinical tool for targeting clinically induced VTs and regions likely to harbor potential VTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.14181","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T14:36:09Z","timestamp":1612362969000},"page":"432-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Feasibility study shows concordance between image\u2010based virtual\u2010heart ablation targets and predicted ECG\u2010based arrhythmia exit\u2010sites"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-8921","authenticated-orcid":false,"given":"Shijie","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-0133","authenticated-orcid":false,"given":"Eric","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adityo","family":"Prakosa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos N.","family":"Aronis","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology Division of Cardiology Department of Medicine Johns Hopkins Hospital  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-3019","authenticated-orcid":false,"given":"Jonathan","family":"Chrispin","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology Division of Cardiology Department of Medicine Johns Hopkins Hospital  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishna","family":"Tandri","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology Division of Cardiology Department of Medicine Johns Hopkins Hospital  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"AbdelWahab","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth II Health Sciences Centre  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Milan","family":"Hor\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Sapp","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth II Health Sciences Centre  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Trayanova","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University  Baltimore Maryland USA"},{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.3.289"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.070"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513614"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.093764"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030187.39852.A7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.062"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.03.014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.02.024"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0282-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008262"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004726"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.312090"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11437"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653568"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0593-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-018-02168-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.73"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613773"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.044"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.14181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T07:42:34Z","timestamp":1693640554000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/pace.14181"],"URL":"https:\/\/doi.org\/10.1111\/pace.14181","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,12]]},"assertion":[{"value":"2020-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}