{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:41Z","timestamp":1747187381701,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) is a well\u2010established treatment for patients with drug refractory heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study sought to compare the longest RV<jats:sub>sense<\/jats:sub> to LV<jats:sub>sense<\/jats:sub> activation time (sLAT) versus the longest RV<jats:sub>pace<\/jats:sub> to LV<jats:sub>sense<\/jats:sub> activation time (pLAT) as the programmed site for left ventricular (LV) pacing in CRT patients with quadripolar LV leads at 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single site, double\u2010blinded, prospective trial, randomized patients 1:1 into the sLAT or pLAT group to determine response. LV pacing was programmed at implant and maintained through 3 months of follow\u2010up. The 6\u2010minute hall walk (6MHW) test, NYHA, Minnesota living with heart failure, and clinical composite score (CCS) at the 3 months was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>N<\/jats:italic>\u00a0=\u00a092 patients (73M:19F age 66 \u00b1 11.3 years) were randomized implanted and programmed per protocol. Baseline characteristics were comparable. <jats:italic>N<\/jats:italic>\u00a0=\u00a039 sLAT and <jats:italic>N<\/jats:italic>\u00a0=\u00a034 pLAT completed the 3\u2010month visit for final analysis. Significant improvement from baseline to 3 months was seen in the sLAT group from 253.9 (+\/\u221211.5) to 323.1 (+\/\u221211.9) <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001. Similarly, the pLAT group improved from 274.9 (+\/\u221216.15) to 343.9 (+\/\u221215.9) <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003. The difference between these groups, however, did not reach significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.86). The pLAT group demonstrated a higher responder rate of (71%) versus the sLAT group (64%) based on the CCS although not reaching significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of both the pLAT and sLAT method of programming demonstrated significant improvement in 6MHW distance at 3 months with pLAT demonstrating a slightly higher responder rate based on CCS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.56). pLAT should be considered at minimum as equivalent in patients with no intrinsic conduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14212","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T09:06:54Z","timestamp":1614935214000},"page":"967-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paced or sensed conduction time to determine programming with cardiac resynchronization therapy: The PASED\u2010CRT Trial"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-2071","authenticated-orcid":false,"given":"Raffaele","family":"Corbisiero","sequence":"first","affiliation":[{"name":"Deborah Heart &amp; Lung Center  Browns Mills New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoEllen","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Deborah Heart &amp; Lung Center  Browns Mills New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Muller","sequence":"additional","affiliation":[{"name":"Abbott Laboratories  Sicklerville New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Sookhu","sequence":"additional","affiliation":[{"name":"Deborah Heart &amp; Lung Center  Browns Mills New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meet","family":"Shah","sequence":"additional","affiliation":[{"name":"Deborah Heart &amp; Lung Center  Browns Mills New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ochman","sequence":"additional","affiliation":[{"name":"Deborah Heart &amp; Lung Center  Browns Mills New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Kazemain","sequence":"additional","affiliation":[{"name":"Deborah Heart &amp; Lung Center  Browns Mills New Jersey 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