{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:51Z","timestamp":1787755371352,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cryoballoon ablation for the treatment of patients with atrial fibrillation (AF) has been utilized in Europe for &gt;15 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Report patient and procedural characteristics that influence the safety of cryoablation for the treatment of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients enrolled in the prospective, multicenter <jats:italic>Cryo AF Global Registry<\/jats:italic> were treated at 38 European centers. Freedom from a \u226530s episode of AF\/atrial flutter (AFL)\/atrial tachycardia (AT) at 12\u2010months and serious complications were analyzed. Univariate and multivariable models identified baseline patient and procedural characteristics that predicted a procedure\u2010related complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1418 subjects who completed an index procedure, the cohort was 62 \u00b1 11 years of age, 37.7% female, and 72.2% paroxysmal AF (PAF). The mean procedure, left atrial dwell, and fluoroscopy times were 81 \u00b1 34, 54 \u00b1 25, and 14 \u00b1 13 min, respectively. Among the 766 patients with 12\u2010month follow\u2010up, freedom from a \u226530 s AF\/AFL\/AT recurrence was 83.3% (95% CI: 79.8%\u201386.3%) and 71.6% (95% CI: 64.6%\u201377.4%) in patients with PAF and persistent AF. The serious procedure\u2010 and device\u2010related adverse event rates were 4.7% and 2.0%. No baseline patient characteristic independently predicted a procedure\u2010related adverse event; however, prolonged procedure duration (OR = 1.01 [95% CI: 1.00\u20131.01]), use of general anesthesia (OR = 1.71 [95% CI: 1.01\u20132.92]), and delivery of a cavotricuspid isthmus line (OR = 3.04 [95% CI: 1.01\u20139.20]) were each independently associated with the occurrence of a serious procedural safety event (all <jats:italic>p<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cryoballoon ablation is safe and effective in real\u2010world use across a broad cohort of patients with AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14237","type":"journal-article","created":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T10:38:32Z","timestamp":1617532712000},"page":"883-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety of cryoballoon ablation for the treatment of atrial fibrillation: First European results from the cryo AF Global Registry"],"prefix":"10.1111","volume":"44","author":[{"given":"Csaba","family":"F\u00f6ldesi","sequence":"first","affiliation":[{"name":"Gottsegen Gy\u00f6rgy Orsz\u00e1gos Kardiol\u00f3giai Int\u00e9zet  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Misikov\u00e1","sequence":"additional","affiliation":[{"name":"V\u00fdchodoslovensk\u00fd \u00fastav srdcovych a cievnych chor\u00f4b  a.s. Ko\u0161ice Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Ptaszy\u0144ski","sequence":"additional","affiliation":[{"name":"Medical University of \u0141\u00f3d\u017a, Central University Hospital  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Todd","sequence":"additional","affiliation":[{"name":"Liverpool Heart and Chest Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Manuel","family":"Herzet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional de la Citadelle  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra M.","family":"Braegelmann","sequence":"additional","affiliation":[{"name":"Medtronic, Inc.  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred J.","family":"Kueffer","sequence":"additional","affiliation":[{"name":"Medtronic, Inc.  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Drephal","sequence":"additional","affiliation":[{"name":"Sana Klinikum Berlin Lichtenberg Klinik f\u00fcr Innere Medizin II, Kardiologie  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Steinwender","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kepler University Hospital Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Zucchelli","sequence":"additional","affiliation":[{"name":"Second Division of Cardiology, Cardiac Thoracic and Vascular Department Azienda Ospedaliero Universitaria Pisana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Neuzil","sequence":"additional","affiliation":[{"name":"Na Homolce Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Ryul Julian","family":"Chun","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien  Frankfurt Germany"},{"name":"Med. Klinik II Universt\u00e4tsklinikum Schleswig\u2010Holstein  Campus L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.064"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"issue":"20","key":"e_1_2_10_4_1","first-page":"30603","article-title":"Cryoballoon ablation of pulmonary veins for persistent atrial fibrillation: results from the multicenter STOP Persistent AF trial","volume":"1547","author":"Su WW","year":"2020","journal-title":"Heart Rhythm"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.07.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz155"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy452"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13799"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14614"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12961"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14547"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006204"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.04.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.04.020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000760"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01920.x"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.14237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T12:58:17Z","timestamp":1693573097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/pace.14237"],"URL":"https:\/\/doi.org\/10.1111\/pace.14237","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"2020-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}