{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:18:39Z","timestamp":1775207919167,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolated left bundle branch block (LBBB) aberrancy is exceedingly rare in the young and its clinical and genetic determinants remain poorly characterized. Furthermore, there is conflicting data on its natural history in the pediatric age group patients. We report the rare phenotype of isolated typical LBBB aberrancy in two healthy children, one of whom carried a likely pathogenic mutation in the coding exon 1 of <jats:italic>NKX2\u20105<\/jats:italic> (p.Q22R, c.65A\u00a0&gt;\u00a0G, rs201442000). Our findings suggest that isolated LBBB aberrancy could be non\u2010progressive in some children, at least in the short term. However, given the paucity of data on this entity, we recommend continued long\u2010term surveillance.<\/jats:p>","DOI":"10.1111\/pace.14243","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T13:49:58Z","timestamp":1617976198000},"page":"1466-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolated left bundle branch block in the young: case reports and review of literature"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-840X","authenticated-orcid":false,"given":"Utkarsh","family":"Kohli","sequence":"first","affiliation":[{"name":"Section of Pediatric Cardiology Department of Pediatrics Comer Children's Hospital and the Pritzker School of Medicine of the University of Chicago  Chicago Illinois USA"},{"name":"Section of Pediatric Cardiology Department of Pediatrics West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenni S.","family":"Sriram","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Children's Hospital of Michigan Central Michigan University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemal M.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Care Heart and Vascular Center Pritzker School of Medicine of the University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12572"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.43.2.164"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104795110400112X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.044"},{"key":"e_1_2_7_6_1","first-page":"184\u2010186","article-title":"Isolated left bundle branch block progressing to complete heart block and asystole: a novel presentation of a desmin mutation","volume":"4","author":"Gearhart AS","year":"2018","journal-title":"HeartRhythm Case Rep"},{"key":"e_1_2_7_7_1","first-page":"464579","article-title":"Isolated left bundle branch block in a toddler","volume":"2014","author":"Agrawal H","year":"2014","journal-title":"Case Rep 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