{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:03:57Z","timestamp":1787321037331,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Several studies have explored premature atrial complexes (PACs) as high\u2010risk factors for atrial fibrillation (AF) in ischemic stroke patients; however, the results were controversial. The aim of this systematic review and meta\u2010analysis was to examine whether PACs can predict AF in ischemic stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We comprehensively searched the published literature in PubMed, Embase, and Wiley\u2010Cochrane library databases from inception through August 18, 2020. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed by the fixed\u2010effect model or the random\u2010effect model based on heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 12 eligible studies including 2340 stroke patients with a mean age of 65.9 years. PACs were highly associated with AF occurrence in stroke (pooled OR: 4.16, 95% CI: 3.06\u20135.65) and cryptogenic stroke patients (pooled OR: 3.72, 95% CI: 2.66\u20135.20). Subgroup analysis showed PAC presence and frequent PACs were correlated with stroke in AF patients (pooled OR: 3.72, 95% CI: 1.65\u20138.36 and pooled OR: 5.12, 95% CI: 3.12\u20138.41, respectively). Frequent PACs were identified as the risks for asymptomatic AF (OR: 6.18, 95% CI: 3.23\u201311.83) and future AF occurrence (OR: 3.71, 95% CI: 2.62\u20135.26) in stroke patients. The definition of frequent PACs was inconsistent, and was &gt;70 beats\/24\u00a0h based on Holter monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PACs confer high risks for asymptomatic AF and future AF occurrence in stroke patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.14302","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T08:48:24Z","timestamp":1624610904000},"page":"1599-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Premature atrial complexes can predict atrial fibrillation in ischemic stroke patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-3384","authenticated-orcid":false,"given":"Yirao","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai East Hospital Shanghai Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Heart Failure, Shanghai East Hospital Shanghai Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Dalian Medical University  Dalian Liaoning 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